The effect of endotoxin on the body temperature of mice was studied in animals housed without bedding at an environmental temperature of 15 C. Rectal temperatures were measured during the initial 3 to 5 hr of exposure. Doses of endotoxin ranging from 0.01 to 1 ld(50), as determined for mice maintained at 25 C, produce a hypothermia in proportion to dose. Concurrent injection of tryptophan magni...

Background: Previous reports suggest flavonoids as potent analgesic compounds. Objectives: Based on these observations, the present study investigated anti-nociceptive action of troxerutin and neural interactions with opioidergic, serotoninergic, nitrergic systems in mice. Methods: A total 340 male mice were randomly divided into 2 categories. Each category included four experiments groups. In ...

Rosemary (Rosmarinus officinalis) is a common household plant grows in many parts of the world, including Iran. Rosemary leaves are used in folk medicine as an antispasmodic, analgesic, diuretic and ntiepileptic agent. The objective of this study was to investigate the antinociceptive mechanisms of rosemary extract using a writhing test as a model of visceral pain. Possible antinociceptive mech...