BACKGROUND Intravenous tobramycin (three-times daily) is widely used for pulmonary exacerbations in patients with cystic fibrosis who have chronic Pseudomonas aeruginosa infection. We undertook a double-blind, randomised controlled trial to assess the safety and efficacy of once versus three-times daily tobramycin in these patients. METHODS 244 patients from 21 cystic-fibrosis centres in the ...

BACKGROUND Whether sonography is an appropriate imaging modality for cervical lymph nodes in patients with papillary thyroid microcarcinoma (PTMC) remains unclear. Hence, this study aimed to evaluate the diagnostic value of ultrasonography (US) features for lymph node metastasis in PTMC. METHODS Seven hundred twelve patients with PTMC who underwent conventional ultrasonography examinations of...

Congenital cystic adenomatoid malformation (CCAM) of the lung is a rare pulmonary lesion. The prognosis is variable ranging from perinatal death to spontaneous in utero regression, with no neonatal morbidity. We present a case of CCAM diagnosed at 23 weeks' gestation using results of prenatal sonograms. Both prenatal Two-Dimensional and Three-Dimensional sonograms revealed multiple cystic lesio...

QUESTION : Can a session of exercise with incorporated expiratory manoeuvres substitute for a session of breathing techniques for airway clearance in children with cystic fibrosis? Are children with cystic fibrosis as co-operative and satisfied with the exercise regimen as with the breathing techniques?. DESIGN Randomised, cross-over trial with concealed allocation and intention-to-treat anal...

INTRODUCTION Cystic lesions of the upper abdomen normally develop from pancreatic tissue. The differential diagnoses include neoplastic and non-neoplastic lesions. Pseudocystic tumors that secondarily involve the pancreas are very rare and may lead to diagnostic pitfalls. CASE PRESENTATION A 51-year-old woman and a 65-year-old man, both German, presented with abdominal cystic lesions suspecte...

In 1935 Stein and Leventhal described seven hirsute and infertile women with amenorrhoea or oligomenorrhoea in whom bilateral cystic ovarian enlargement was found at laparotomy' and thereby gave their names to a polycystic ovarian disorder. Since then, however, the protean manner of clinical presentation and the variability of biochemical changes in patients with this condition have led some pe...

BACKGROUND Proinflammatory cytokines stimulate osteoclast activity and this could lead to increased bone resorption in patients with cystic fibrosis. The aim of this study was to determine whether markers of systemic inflammation are related to changes in bone mineral content (BMC) in adults with cystic fibrosis. METHODS Total body BMC was assessed by dual energy x ray absorptiometry in 100 p...

background evaluation of the accuracy and performance of sonography units needs tissue-mimicking phantoms. these phantoms play an important role by simulating soft tissues, obviating the need to experiment on humans or animals. objectives to present a simple sonographic phantom for quality control and training purposes. materials and methods the presented phantom consists of a two-part plexigla...

Ultrasonography (US) features of thyroid nodules can be helpful in identifying those most at risk for malignancy; these include marked hypoechogenicity, microcalcifications, irregular margins, and a taller-than-wide shape (nonparallel orientation). Some cystic change morphologically after simple aspiration percutaneous ethanol injection treatment. They show hypoechogenicity margins on the US di...

Cystic change in metastatic lymph nodes of papillary thyroid carcinoma (PTC) is a diagnostic challenge for fine needle aspiration (FNA) because of the scant cellularity. The aim of this study was to evaluate the measurement of thyroglobulin in fine needle aspirate (Tg-FNA) for detecting metastatic PTC in patients with cystic neck lesions and to validate the optimal cutoff value of Tg-FNA. A tot...