Cytomegalovirus (CMV) retinitis is a common opportunistic infection in patients with AIDS. With long-term therapy for CMV retinitis, resistant CMV may develop. In a prospective study of 122 patients with CMV retinitis, 2.4 and 0.8% of patients had foscarnet-resistant blood culture isolates (50% inhibitory concentration [IC50], >400 microM) and urine culture isolates, respectively, at diagnosis ...

cytomegalovirus (cmv) infection is one of the most common infections that affects humans’ cardiovascular system. although the literature includes controversial evidence for any correlation between cmv infection and arterial atherosclerosis, the majority of studies, especially those with larger patient population and stronger data stand for such a relationship. however, the number of prospective...

evidences from many studies suggested a polymerase chain reaction (pcr) as a valuable method for diagnosing infectious disease in the transplant recipients. we used this method for detection of toxoplasma, gondii and human cytomegalovirus in blood specimens from patients after bone marrow or kidney transplantation. dna of both infectious agents were detected using two separate sets of nested pr...

introduction:torch infections causing via toxoplasma gondii, other microorganisms (e.g., treponema pallidum), rubella virus, cytomegalovirus (cmv) and the herpes simplex virus (hsv) types 1 and 2 during the first trimester of pregnancy can lead to severe fetal anomalies or even fetal loss. the current study determined the serological data of torch infections in women who were in their first tri...

The study of human cytomegalovirus (HCMV) antiviral drug resistance has enhanced knowledge of the virological targets and the mechanisms of antiviral activity. The currently approved drugs, ganciclovir (GCV), foscarnet (FOS), and cidofovir (CDV), target the viral DNA polymerase. The widespread use of ganciclovir (GCV) to treat cytomegalovirus (CMV) infections in immuno-suppressed patients has l...

Cytomegalovirus (CMV) colitis occurs commonly in immunocompromised patients with high mortality. CMV infection has also been reported immunocompetent individuals and it a varied clinical presentation. When HIV-infected are started on antiretroviral therapy (ART) there is reconstitution of the immune system which results paradoxical worsening existing conditions or development new disease known ...

Human adenoviruses are frequent cause of slight self-limiting infections in immune competent subjects, while causing life-threatening and disseminated diseases in immunocompromised patients, particularly in the subjects affected by acquired immunodeficiency syndrome and in bone marrow and organ transplant recipients. Here, infections interest lungs, liver, encephalon, heart, kidney and gastro e...

Antilymphocyte therapies are widely used for immunosuppression in solid organ transplantation. These agents have varied mechanisms of action, with resulting differences in the intensity and duration of immunosuppression and in associated infectious complications. Induction therapy with antithymocyte globulins is associated with a greater incidence of cytomegalovirus, Epstein-Barr virus, and BK ...

Although infections are a major concern in patients with primary systemic vasculitis, actual knowledge about risk factors and evidence concerning the use of anti-infective prophylaxis from clinical trials are scarce. The use of high dose glucocorticoids and cyclophosphamide pose a definite risk for infections. Bacterial infections are among the most frequent causes of death, with Staphylococcus...

Pneumocystis jirovecii pneumonia (PJP) is difficult to be diagnosed, so this study explored if PJP could diagnosed by metagenomic next-generation sequencing (mNGS) and mNGS guide the therapy of PJP. was successfully 13 out 14 recipients with 11 through peripheral blood samples, verified PCR. Ten non-PJP were enrolled as control group. Blood tests revealed a high β-D-glucan (BDG) level in all du...