Background: Aberrant methylation of cytosine-guanine dinucleotide islands leads to inactivation of tumor suppressor genes in breast cancer. Tumor suppressor genes are unmethylated in normal tissue and often become hypermethylated during tumor formation, leading to gene silencing. We investigated the association between E-cadherin (CDH1) and estrogen receptor-α (ESRα) gene promoter methylation a...

Experimental studies of excitation thymine, guanine, cytosine, uracil, which are the basis biological structure DNA and RNA, contribute to study mechanisms their destruction under influence low-energy β-radiation ultraviolet radiation. Crystal chemical analysis cytosine molecule showed that it exists in two crystalline forms crystallize orthorhombic syngony, but different space groups (form Cyt...

Changes in DNA methylation patterns is a prominent characteristic of human tumors. Tumor cells display reduced levels of genomic DNA methylation and site-specific CpG island hypermethylation. Methylation of CpG dinucleotides is catalyzed by the enzyme family of DNA methyltransferases (DNMTs). In this review, the role of DNA methylation and DNMTs as key determinants of carcinogenesis is further ...