نتایج جستجو برای: cytotoxin associated gene acaga

تعداد نتایج: 2427272  

Journal: :The Journal of antimicrobial chemotherapy 2001
J Wiström S R Norrby E B Myhre S Eriksson G Granström L Lagergren G Englund C E Nord B Svenungsson

The frequency of antibiotic-associated diarrhoea (AAD) and Clostridium difficile-associated diarrhoea (CdAD) was prospectively determined in a population of 2462 patients recruited from five Swedish hospitals, including divisions for infectious diseases, orthopaedics, surgery, geriatrics, nephrology and internal medicine. AAD developed in 4.9% of the treated patients. Faecal samples were obtain...

Journal: :Journal of clinical microbiology 2014
Ameer A Memon Nawfal R Hussein Véronique Y Miendje Deyi Alain Burette John C Atherton

The Helicobacter pylori virulence gene, cagA, and active forms of the vacuolating cytotoxin gene, vacA, are major determinants of pathogenesis. However, previous studies linking these factors to disease risk have often included patients using aspirin/nonsteroidal anti-inflammatory agents (NSAIDs) or acid-suppressing drugs, both of which may confound results. Also, particularly for gastric cance...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Isabella M Toller Kai J Neelsen Martin Steger Mara L Hartung Michael O Hottiger Manuel Stucki Behnam Kalali Markus Gerhard Alessandro A Sartori Massimo Lopes Anne Müller

The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer. The molecular mechanisms of H. pylori-associated gastric carcinogenesis remain ill defined. In this study, we examined the possibility that H. pylori directly compromises the genomic integrity of its host cells. We provide evidence that th...

Journal: :The European respiratory journal 1999
K W Tsang W K Lam E Kwok K N Chan W H Hu G C Ooi L Zheng B C Wong S K Lam

The recently reported increase in seroprevalence of Helicobacter pylori, the causative pathogen in peptic ulceration, in bronchiectasis is unexplained. Therefore, the association of antibodies directed against cytotoxin-associated gene A(CagA), whose expression indicates virulence of H. pylori, and upper gastrointestinal symptoms in patients with stable bronchiectasis and healthy volunteers eva...

Journal: :iranian journal of basic medical sciences 0
leila hasanzadeh ¹ department of biotechnology and microbiology, school of medicine, arak university of medical sciences, arak, iran ehsanollah ghaznavi-rad department of microbiology and immunology, school of medicine, arak university of medical sciences, arak, iran safieh soufian ³biology department, payame noor university, arak, iran vahideh farjadi department of microbiology, islamic azad university, qom branch, qom, iran hamid abtahi molecular and medicine research center, department of microbiology, school of medicine, arak university of medical sciences, arak, iran

objective(s): helicobacter pylori, a human specific gastric pathogen is a causative agent of chronic active gastritis. the vacuolating cytotoxin (vaca) is an effective virulence factor involved in gastric injury. the aim of this study was to construct a recombinant protein containing antigenic region of vaca gene and determine its antigenicity.   materials and methods: the antigenic region of v...

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