PURPOSE This study was designed to measure vitamin D metabolites in the aqueous and vitreous humor and in tear fluid, and to determine if dietary vitamin D3 supplementation affects these levels. We also determined if the corneal epithelium can synthesize vitamin D following UV-B exposure. METHODS Rabbits were fed a control or vitamin D3 supplemented diet. Pilocarpine-stimulated tear fluid was...

CONTEXT Two reports suggested that vitamin D2 is less effective than vitamin D3 in maintaining vitamin D status. OBJECTIVE Our objective was to determine whether vitamin D2 was less effective than vitamin D3 in maintaining serum 25-hydroxyvitamin D levels or increased the catabolism of 25-hydroxyvitamin D3. SUBJECTS AND DESIGN This was a randomized, placebo-controlled, double-blinded study ...

The effectiveness of the latest genetic technologies in advancing diagnosis growth hormone deficiency (GHD) and predicting response to recombinant human (rHGh) therapy has been insufficiently studied. polymorphism GHR-exon 3 considered as a possible predictor replacement therapy, but data obtained are contradictory. Purpose - identify allelic variants receptor gene (GHR-exon 3) children with GH...

CYP11A1 can hydroxylate vitamin D3 at carbons 17, 20, 22, and 23, producing a range of secosteroids which are biologically active with respect to their ability to inhibit proliferation and stimulate differentiation of various cell types, including cancer cells. As 1a-hydroxylation of the primary metabolite of CYP11A1 action, 20S-hydroxyvitamin D3 [20(OH)D3], greatly influences its properties, w...

Linear complementary dual (LCD) codes are linear that intersect with their trivially. We study the largest minimum weight d2(n,k) among all binary LCD [n,k] and d3(n,k) ternary codes. The weights d2(n,5) d3(n,4) partially determined. also determine d2(n,n−5), d3(n,n−i) for i∈{2,3,4}, n∈{11,12,…,19}.

introduction:  results: these findings revealed the exaggerated responses in the group which received cci. the group which was treated by 1 μg/kg of 1,25 vit d3 showed a significant reduction in pain behavior. injection of 1,25 vit d3 did not change the response of animals to the acetone drop and von frey filament. discussion: our results showed that antinoceptive effect of 1,25 vit d3 in a rod...

Background: Leukocyte infiltration into the central nervous system (CNS) in diseases like multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) have been implicated in subsequent disease pathogenesis and progression. It suggested that vitamin D3 (active form of vitamin D) ameliorates the symptoms of EAE when administered after the onset of clinical sings. The aim of this s...

The role of the prohormone vitamin D3 in regulating calcium and phosphate metabolism in the intestine, kidney, and bone has been known for several decades. Recent studies have provided evidence that vitamin D3, may also play an important role in regulating metabolism in other organs, including heart. This role has been suggested by the identification of a specific receptor for 1,25-dihydroxyvit...