Once-daily aminoglycoside dosing is effective in treating gram-negative infections, including those associated with bones and joints.

?+orl the . The wise physician has never underrated importance of diet in the treatment o but at the beginning of the present ce western countries the field of dietetics, 1 ,, as it was applied to the general SUPP , , healthy population, was mamly . ? jg cranks, who were as wrong in most of and fancies and in the baseless theories Propounded as they were right m their in that more attention sho...

Psychopathy is a personality disorder characterized by a set of diverse traits—interpersonal antagonism, disinhibition, narcissism, and emotional instability. Previous theorizing suggests that these different traits may underlie distinct behaviors. The present study used ecological momentary assessment (EMA) to examine the relations between the different self-reported psychopathy traits and the...

Chronic daily headache (CDH) is a heterogeneous group of headaches that includes primary and secondary varieties. Primary CDH is a frequent entity that probably affects 4% to 5% of the population. It can be subdivided into headaches of short duration (less than 4 hours per attack), like chronic cluster headache, and disorders of long duration (greater than 4 hours per attack). Primary CDH of lo...

Downscaling of daily precipitation with a stochastic weather generator for the subtropical region in South China Y. D. Chen, X. Chen, C.-Y. Xu, and Q. Shao Department of Geography and Resource Management, The Chinese University of Hong Kong, Shatin, Hong Kong, China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Hohai University, Nanjing, China Department of Geosci...

Chronic daily headache, defined as headache on 15 days or more per month for more than three months, is covered generally in another section of this supplement. However, because the syndrome of “new daily persistent headache” (NDPH) is so clinically distinct (table 1), and has an interesting range of secondary possibilities that are curable, we have elected to highlight the problem here. This i...

Biological timekeeping is determined by internal temporal programmes and the resetting of these programmes or clocks by external stimuli. Many of the core genes of the mammalian daily or circadian clock are known, but the factors regulating so-called 'clock' gene proteins are unclear. In this issue of the Biochemical Journal, Gallego and colleagues show for the first time that protein phosphata...

BACKGROUND A prolonged-release formulation of tacrolimus (Tacrolimus QD) was developed to allow once-daily dosing and to have similar safety and efficacy profiles to twice-daily tacrolimus (Tacrolimus BID). This study compared the pharmacokinetics (PK) and renal pathology by protocol biopsy in de novo living kidney transplant recipients treated with either low-dose Tacrolimus QD or Tacrolimus B...