A 70-year-old female patient was admitted to our hospital because of atypical chest pain and fatigue. No relevant diseases were recorded in her previous medical history. During the physical examination, she presented with a mild systolic murmur. Her 12-lead ECG indicated right bundle branch block (Figure 1A), and blood pressure was normal. Initial blood test showed normal hs-Troponin T and D-di...

Glycogen storage disease may affect the heart, particularly as result of a mutation of the LAMP2 and PRKAG2 genes encoding for structural proteins of cardiomyocytes.1 Its recognition and differentiation from hypertrophic cardiomyopathy and other infiltrative and storage diseases may influence treatment and prognosis but are difficult to obtain by conventional noninvasive imaging. A 26-year-old ...

Anderson-Fabry disease (E C 3.2.1.22, MIM 301500) is an X linked lysosomal storage disorder caused by a deficiency of the enzyme α-galactosidase A (GLA). 2 The onset of the disease and the severity of clinical manifestations depend principally on residual GLA enzymatic activity. Fabry disease can be classified into two clinical phenotypes: the classical form and the cardiac variant. 3 The class...

Anderson-Fabry disease (E C 3.2.1.22, MIM 301500) is an X linked lysosomal storage disorder caused by a deficiency of the enzyme α-galactosidase A (GLA). 2 The onset of the disease and the severity of clinical manifestations depend principally on residual GLA enzymatic activity. Fabry disease can be classified into two clinical phenotypes: the classical form and the cardiac variant. 3 The class...

Over the past 20 years, researchers investigating the mitochondria of plants have been astonished by the phenomenal variation these organelles display relative to their mammalian and fungal counterparts. Plant mitochondria have evolved distinct strategies for genome maintenance, genetic decoding, gene regulation, and organelle segregation. Their physiological and biochemical functions have simi...

The social phenomenon of familiar strangers was identified by Stanley Milgram in 1972 with a small-scale experiment. However, there has been limited research focusing on uncovering the phenomenon at a societal scale and simultaneously investigating the social relationships between familiar strangers. With the help of the large-scale mobile phone records, we empirically show the existence of the...

networks have been used to study complex interactions between many different types of actors (Boccaletti et al. 2006). These actors and interactions represent a range of applications including social connections among people (Holland and Leinhardt 1970; Haynie 2002; Gleiser and Danon 2003), games and economics (Kim et al. 2002; Ebel and Bornholdt 2002; Holme et al. 2003), protein-protein intera...

Signaling through the redox active molecule hydrogen peroxide (H2O2) is important for several processes in plants, such as stomatal closure, root growth, gravitropism, and responses to pathogen challenge (Neill et al., 2002; Laloi et al., 2004). Although oxidative modification of reactive Cys residues within proteins hasbeen suggested as ameans bywhichH2O2 signaling can activate responses such ...

The crystal structure of vivianite contains Fe2* ions in isolated Fef,* octahedra and in pated fet"* octahedra. Mcissbauer spectral measurements of vivianites mechanically ground in air demonstrate that Fe3*/Fel* increases with rising Fe3* concentration, suggesting that there is a greater probability of oxidizing remaining Fef,* ions than the second Fe2s* ion of an existing n!3*-fe."* pair. A m...

Signaling through the redox active molecule hydrogen peroxide (H2O2) is important for several processes in plants, such as stomatal closure, root growth, gravitropism, and responses to pathogen challenge (Neill et al., 2002; Laloi et al., 2004). Although oxidative modification of reactive Cys residues within proteins hasbeen suggested as ameans bywhichH2O2 signaling can activate responses such ...