fire blight, caused by the bacterium erwinia amylovora, is one of the most destructive diseases of plants in the rosaceae subfamily pomoideae. the objective of this study was to determine the level of resistance of 30 pear cultivars and describe the biochemical changes induced in some resistant and susceptible cultivars. the level of resistance was determined by the length of the fire blight le...

We aimed to investigate the microbial diversity, mine lignocellulose-degrading enzymes/proteins, and analyze domain structures of mined enzymes/proteins in humus samples collected from Cuc Phuong National Park, Vietnam. Using a high-throughput Illumina sequencer, 52 Gbs DNA were assembled 2,611,883 contigs, which 4,104,872 open reading frames (ORFs) identified. Among total microbiome analyzed, ...

UNLABELLED Isolated GH deficiency type IA (IGHDIA) is an infrequent cause of severe congenital GHD, often managed by pediatric endocrinologists, and hence few cases in adulthood have been reported. Herein, we describe the clinical status of a 56-year-old male with IGHDIA due to a 6.7 kb deletion in GH1 gene that encodes GH, located on chromosome 17. We also describe phenotypic and biochemical p...

Chitinases of the GH18 family play important roles in a variety of pathogenic organisms and have also been shown to be involved in human asthma progression, making these enzymes potential drug targets. While a number of potent GH18 chitinase inhibitors have been described, in general, these compounds suffer from limited synthetic accessibility or unfavorable medicinal-chemical properties, makin...

Heat shock proteins (HSPs) have proven to be effective tools for extending invertebrate lifespan, and in C. elegans daf-2 mutants, longevity resulting from loss of insulin/insulin-like signals is at least partly dependent upon elevated HSP expression. In mice, inhibition of the orthologous growth hormone/insulin-like growth factor I (GH/IGF-I) pathway has similar pro-longevity effects. A recent...