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Neoadjuvant therapy combining immunotherapy (IO) and chemotherapy (CT) is the standard of care in early-stage triple-negative breast cancer (ESTNBC), following results KEYNOTE-522. However, overall survival (OS) gain uncertain so far. This study aims to evaluate long-term outcomes neoadjuvant IO plus CT for ESTNBC. We conducted a systematic review using PubMed, Embase, Cochrane databases until ...

Abstract Introduction Frostbite in children is very rare with few citations the literature. Thrombolytic therapy commonly used to salvage threatened tissue frostbitten adults, but there little no data on use of such children. The aim this case series advance our understanding pediatric frostbite by describing risk factors and outcomes, as well commenting safety thrombolytic population. To knowl...

Social network analysis is a rapidly expanding field for interpreting the interplay of relationships in the past. Scholars of the ancient Mediterranean and Near East have experimented with technologies of network analysis in attempts to approach numerous historical and archaeological questions from a new perspective. However, due to the fragmentary nature of our data, the complexities of past s...

F. Joannes met au jour deux moments de crise dans les relations entre Cambyse, d’abord prince heritier et ensuite roi l’empire Achemenide, autorites babyloniennes. Ces crises ont amene ces dernieres a se tourner finalement vers Bardiya. Meme si la conquete Babylonie par Cyrus s'est faite sans grandes difficultes, elle n’a pas debouche sur mise en place immediate d’une administration imperiale e...

Vitiligo is an inflammatory disease that presents as well-demarcated, depigmented skin lesions. While different mechanisms are implicated in the development and maintenance of vitiligo lesions, immune-mediated destruction melanocytes has been ascribed major mechanism depigmentation. We have previously observed enrichment cytotoxic resident CD49a+ CD103+ T-cells patients recent single cell data ...

The PIK3C3 locus was implicated in case-case genome-wide association study of systemic lupus erythematosus (SLE) which we had performed to detect genes associated with autoantibodies and serum interferon-alpha (IFN-alpha). Herein, we examine a PIK3C3 promoter variant (rs3813065/-442 C/T) in an independent multiancestral cohort of 478 SLE cases and 522 controls. rs3813065 C was strongly associat...