Sézary cells (SC) (synonyms: mycosis cell, Lutzner cell, cerebriform lymphocytes, Atypia Cellules Monstreuses or monster cell) are atypical lymphocytes with a grooved or cerebriform nucleus seen both in tissue and blood. They are characteristically seen in cutaneous T cell lymphomas including mycosis fungoides (MF). The Sézary cell is named after the French dermatologist Sézary A (1880-1956). S...

Sino-nasal mycosis is a known complication in patients with immunological or metabolic compromise. Mainstay of treatment includes reversal of the compromised state, systemic antifungals and repeated radical debridements assisted by serial imaging. Salvage is possible provided no cerebral extension exists on presentation. The resultant deformity following debidement causes gross morbidity and ps...

Mycosis fungoides is a rare type of non-Hodgkin's lymphoma of T cells that primarily affects the skin. It is characterized by the presence of erythematous plaques that evolve into ulcerated lesions, tumors throughout the skin or even bone marrow infiltration in advanced stages. Chemotherapy and topical steroids, phototherapy and radiotherapy are treatment options for early cases. This study rep...

CTCL: cutaneous T-cell lymphoma FOLFOX: folinic acid, fluorouracil, oxaliplatin MF: mycosis fungoides INTRODUCTION Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL). The neoplastic T cells in MF are usually mature CD4 T cells, and CD8 phenotype expression is rarely observed. There are 2 categories of CD8 CTCL, one with aggressive behavior and one with indolent b...

NA WANG****, XIANMEI LU******* & FUREN ZHANG********** * Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, Shandong, China ** Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China *** Shandong Provincial Key Lab for Dermatovenereology, Jinan, Shandong, China **** Shandong Provincial Medical Center for...

A 46-year-old male farmer born in Minas Gerais State, Brazil, presented with disseminated plaque-like, ulcerated skin lesions ( Figure 1A–D ). Laryngoscopy showed lesions on the pharyngeal, nasal, and laryngeal mucosa ( Figure 1E ). He was a heavy tobacco smoker and drank 1–2 L of rum daily. The differential diagnosis included secondary syphilis, sporotrichosis, histoplasmosis, tuberculosis, ch...

Sporotrichosis is a chronic infection usually limited to cutaneous and subcutaneous tissues. It involves all layers of skin and the subcutaneous lymphatic. The disease is caused by a dimorphic fungus Sporothrix schenckii. The fungus, present in nature in a variety of plants and soil, invades through a skin injury. Many times, the injury to the skin is so minor that it goes unrecognized and negl...

Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis, a deep mycosis endemic in Latin America. Studies to elucidate the host-parasite relationship in this mycosis have demonstrated that non-activated phagocytes fail to kill the etiologic agent. Investigations of human monocytes have shown that the lack of fungicidal activity is partially associated with the capacity ...