We propose and mathematically examine a theory of calcium profile formation in unwounded mammalian epidermis based on: changes in keratinocyte proliferation, fluid and calcium exchange with the extracellular fluid during these cells' passage through the epidermal sublayers, and the barrier functions of both the stratum corneum and tight junctions localised in the stratum granulosum. Using this ...

1.1 Skin The evolution of life in the terrestrial environment required the development of a waterproof integument: the skin (Loden and Maibach, 2006). Skin is an extensive organ covering the entire exterior of the body (Stevens and Lowe, 2005). It provides the primary barrier against chemical and biological external agents and water loss (Hadgraft, 2001). The skin also plays an important role i...

Stratum, the de-facto mining communication protocol used by blockchain based cryptocurrency systems, enables miners to reliably and efficiently fetch jobs from mining pool servers. In this paper we exploit Stratum’s lack of encryption to develop passive and active attacks on Bitcoin’s mining protocol, with important implications on the privacy, security and even safety of mining equipment owner...

This study analyses whether ethnic segregation leads to social isolation and lack of access to valuable informal channels into the labour market. We use a survey of Swedish-born young adults in Stockholm, whose parents were born either in Turkey (Stratum T) or in Sweden (Stratum S). Stratum T was randomly sampled, whereas Stratum S was sampled according to the residential distribution of Stratu...

The skin is the largest organ of the body, whose main function is to protect the body against the loss of physiologically important components as well as harmful environmental insults. From the inside to the outside, the skin comprises three major structural layers: the hypodermis, the dermis and the epidermis. The epidermis contains four different sublayers, the stratum corneum (SC), stratum g...

The primary defence mechanism of fish exposed to an infectious or damaging agent is the physical barrier of skin, gills and gastrointestinal tract and their protection mechanisms associated with the innate immune defence system, the mucosal epithelium. Mucus production helps to protect these physical barriers by acting as a diffusion barrier and lubricant whose function is to protect the epithe...

The skin is the largest organ of the body, whose main function is to protect the body against the loss of physiologically important components as well as harmful environmental insults. From the inside to the outside, the skin comprises three major structural layers: the hypodermis, the dermis and the epidermis. The epidermis contains four different sublayers, the stratum corneum (SC), stratum g...

Input-dependent left-right asymmetry of NMDA receptor epsilon2 (NR2B) subunit allocation was discovered in hippocampal Schaffer collateral (Sch) and commissural fiber pyramidal cell synapses (Kawakami et al., 2003). To investigate whether this asymmetrical epsilon2 allocation is also related to the types of the postsynaptic cells, we compared postembedding immunogold labeling for epsilon2 in le...

BACKGROUND The purpose of this study was to determine whether adding the anti-epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib to carboplatin/paclitaxel improved pathologic complete response (pCR) at reassessment surgery in epithelial ovarian, fallopian tube, or primary peritoneal cancers (OFPC). METHODS Patients with stage III-IV OFPC initiated treatment within 12 ...