Particle Size Distribution (PSD) is one of the prime guiding factors granular media response. Degradation via weathering a process, which brings about gradual shift in PSD. In nature, chemically sensitive material like calcite undergoes chemo-mechanical degradation bringing variations their behaviour. present study, an experimental investigation carried out to get insight into mechanical respon...

Solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. The poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. The purpose of the present investigation was to increase the solubility and dissolution rate of carve...

To prepare powdered drugs that do not have a bitter taste, a film coating covering the surfaces of the core particles is required. The dissolution rate of ibuprofen from the coated particles changes according to the physical properties of the core particles. In this study, the effects of the physical properties of granules prepared by using several scales of agitation fluidized beds on the drug...

We explore theoretically the controls on dissolution of salt A, in an under-saturated brine of salts A and B. We show that, as the concentration of B increases, the dissolution rate of A decreases, for brine of given temperature. We also show that there is a sharper decrease in dissolution rate with increasing concentration, for concentrations of B above a critical value, where B limits the equ...

The objective of the study is to prepare, characterize and evaluate starch phosphate, a new modified starch as a carrier in solid dispersions for enhancing the dissolution rate of ritonavir. The feasibility of formulating solid dispersions of ritonavir in starch phosphate into compressed tablets with enhanced dissolution rate was also investigated. Starch phosphate was prepared by reacting star...

This paper presents results of a pharmacokinetics study concerning pentoxifylline and its main metabolites after administration of extended release formulation of Trental 400 mg and correlation of this pharmacokinetics with in vitro dissolution test results of parent drug. In order to establish most relevant in vitro test, dissolution was performed in different experimental conditions (stirring...

Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy. To overcome these limitations, lipid-based formulations have emerged as a promising approach enhance the delivery of such drugs. Moreover, encapsulation within capsules provide convenient dosage form for administration. The t...

The project summarized here investigated some of the parameters and relationships used to predict the performance of limestone contactors. The purpose of the project was to study the effect of limestone composition, especially the dolomite [CaMg(CO 3) 2 ] and impurity content of the stone, on the kinetics of carbonate mineral dissolution and to determine the effect of temperature on the rate of...

Herein we report an approach to assess in vitro cellular responses to the dissolution or degradation products from Fmoc-diphenylalanine (Fmoc-FF) self-assembled hydrogels. Three cell lines were used in these studies and two-way ANOVA was used to assess (i) the age of gel dissolution and degradation products and (ii) exposure time on cell fate and state, using viability assays in conjunction wit...

Governments that procure pharmaceutical products from an Essential Medicine List (EML) bear special responsibility for the quality of these products. In this article we examine the possibility of developing a pharmaceutical product quality risk assessment scheme for use by government procurement officials. We use the Chinese EML as a basis, and US recall data is examined as it is publically ava...