In mathematical physical analyses of Szilard’s engine and Maxwell’s demon, a general assumption (explicit or implicit) is that one can neglect the energy needed for relocating the piston in Szilard’s engine and for driving the trap door in Maxwell’s demon. If this basic assumption is wrong, then the conclusions of a vast literature on the implications of the second law of thermodynamics and of ...

Mesenchymal stem cells (MSCs) have been used in cell-based therapy in various disease conditions such as graft-versus-host and heart diseases, osteogenesis imperfecta, and spinal cord injuries, and the results have been encouraging. However, as MSC therapy gains popularity among practitioners and researchers, there have been reports on the adverse effects of MSCs especially in the context of tu...

Aberrant posttranslational modifications of proteins can impair synaptic plasticity and may render neurons vulnerable to degeneration during aging. In this issue of Neuron, Min et al. show that acetylation of the amino acid lysine in the microtubule-associated protein tau prevents its ubiquitin-mediated degradation, resulting in "tau tangles" similar to those of dementias. Other recent studies ...

The registration of thoracic images is a common but still challenging problem with critical clinical applications (e.g. radiotherapy and diagnosis). In the context of the EMPIRE10 challenge, we briefly introduce in this paper our registration method based on the diffeomorphic demons algorithm. Although fully automatic and generic (applies to a large variety of images such as brain or thoracic C...