Within the field of tissue engineering, natural tissues are reconstructed by combining growth factors, stem cells, and different biomaterials to serve as a scaffold for novel tissue growth. As adequate vascularization and innervation are essential components for the viability of regenerated tissues, there is a high need for easily accessible stem cells that are capable of supporting these funct...

Background and Aim: Childhood overweight and obesity are becoming a major public health concern all over the world. Change in lifestyles and economic growth have led to sedentary lifestyle and altered dietary patterns. The prevalence and incidence of dental caries in a population is influenced by a number of risk factor such as sex, age, socioeconomic status, dietary patterns and oral hygiene h...

Data from three African field sites on Pan troglodytes demonstrate an unambiguous pattern of a slower growth rate in wild vs. captive chimpanzee populations. A revised dental growth chronology for chimpanzees is similar to estimated timing of Homo erectus and therefore has implications for interpreting life history in hominins.

Etiology of Class III malocclusion can be genetic or environmental. Proclination of mandibular incisors and retroclination of maxillary incisors can cause posturing of the mandible in an anterior position due to incisal interference, a condition called pseudo Class III malocclusion that can be misleading in evaluating a patient with skeletal Class III malocclusion. Unfortunately, cephalometric ...

Human dental development is characterized by formation of primary teeth, which are subsequently replaced by the secondary dentition. The secondary dentition consists of incisors, canines, and premolars, which are derived from the successional dental lamina of the corresponding primary tooth germs; and molar teeth, which develop as a continuation of the dental lamina. Currently, very little is k...

Dental trigeminal nerve fiber growth and patterning are strictly integrated with tooth morphogenesis, but it is still unknown, how these two developmental processes are coordinated. Here we show that targeted inactivation of the dental epithelium expressed Fgfr2b results in cessation of the mouse mandibular first molar development at the degenerated cap stage and the failure of the trigeminal m...

Odontoblast differentiation during physiological and reparative dentinogenesis is dependent upon multiple signaling molecules, including fibroblast growth factors (FGFs), bone morphogenetic proteins (BMPs) and Wingless/Integrated (Wnt) ligands. Recent studies in our laboratory showed that continuous exposure of primary dental pulp cultures to FGF2 exerted biphasic effects on the expression of m...