To investigate the control of sugar uptake by metabolic demand, we used isolated quiescent adult rat heart cells in suspension, under conditions similar to those found during anoxia. Metabolic demand was varied by exposing cells to rotenone plus various levels of p-trifluoromethoxyphenylhydrazone. Without glucose, the time taken for half of the cells to undergo contracture was inversely proport...

This paper investigates the implications of an intertemporally dependent demand structure in the market for an exhaustible resource. The demand structure is derived endogenously in a partial equilibrium model where price-taking users combine the resource with capital to produce final output. It is shown that, when demand for the resource is modelled explicitly as a derived demand, the common as...

We study a manufacturing firm that builds a product to stock to meet a random demand. Production time is deterministic, so that if there is a backlog, customers are quoted a firm lead time that is proportional to the backlog. In order to represent the customers’ response to waiting, we introduce a new defection function — the probability that a customer chooses not to order as a function of the...

Dependent types are useful for statically checking detailed specifications of programs and detecting pattern match or array bounds errors. We propose a novel approach to applications of dependent types to practical programming languages: Instead of requiring programmers’ declaration of dependent function types (as in Dependent ML) or trying to infer them from function definitions only (as in si...

Owing to trade imbalance, shipping companies position empty containers between ports or depots periodically. The most difficult problem for positioning is that it is not possible to know the exact amounts of empty containers required in the future. The paper deals with the problem of positioning empty containers in a port area with multiple depots. Customer demands and returning containers in d...

This paper deals with two warehouse inventory model of determining the optimal replenishment policy for non-instantaneous deteriorating items partial backlogging and stock-dependent demand. In the model, shortages are allowed and the backlogging rate is variable and dependent on the waiting time for the next replenishment. The necessary and sufficient conditions of the existence and uniqueness ...

Abstract Customer purchasing deeds may be affected by factors such as selling price and inventory level instead of demand which is considered either constant or function of single variable which is not feasible. Consequently in the present study we have considered demand rate as a function of stock-level and selling price both. In present study, in order to develop this model it has been assume...

A single-item economic production model is developed in which inventory is depleted not only due to demand but also by deterioration. The rate of deterioration is taken to be time dependent, and the time to deterioration is assumed to follow a two-parameter Weibull distribution. The Weibull distribution, which is capable of representing constant, increasing, and decreasing rates of deterioratio...

conclusions there was no meaningful relationship between the mortality rate of patients with mi who were either opium-dependent or non-opium-dependent. the number of re-hospitalizations due to heart problems was meaningfully higher in the opium-dependent patients; hence, educating people and training them on the destructive effects of opium, specifically in patients with heart conditions is hig...