In this paper we model and solve the multi-depot fleet size and mix vehicle routing problem (MDFSMVRP). This problem extends the multi-depot vehicle routing problem and the fleet size and mix vehicle routing problem, two logistics problems that have been extensively studied for many decades. This difficult transportation problem combines complex assignment and routing decisions under the object...

Abstract The interaction of the wheel and rail, being physical basis for movement trains, determines not only such important technical economic indicators railway transport as weight trains their speed, reliability operational life sets, but also foundations operation - safety train traffic. Therefore, studies problems wheel-rail friction pair are relevant in demand within framework a particula...

When transportation plans are developed, problem parameters are often not known with certainty. In addition, the parameters may vary throughout the time period during which the plan is implemented. Thus, improvements can often be made in the quality of such plans by accounting for this variability. However, incorporating stochasticity into problems that are already large-scale and difficult to ...

PURPOSE Peptide drugs for antineoplastic therapies usually have low oral bioavailability and short in vivo half-lives, requiring less preferred delivery methods. Lanreotide depot is a sustained-release somatostatin analog (SSA) formulation produced via an innovative peptide self-assembly method. Lanreotide is approved in the USA and Europe to improve progression-free survival (PFS) in patients ...

Six patients who had experienced prolonged steroid-induced pituitary-adrenal suppression were treated with 100 U of depot procine ACTH every 2 to 4 days for several months. Such treatment did not hasten the recovery of normal pituitary-adrenal function compared with the rate of recovery of a group of similarly suppressed patients who received no depot ACTH. Eight of nine patients who received p...

Generally, progestogens, i.e. progesterone in combination with oestradiol esters, are used primarily in the treatment of menstrual irregularities to maintain endangered pregnancies. Their derivatives are orally active medroxyprogesterone acetate including hydroxyprogesterone caproate, chlormadinone acetate, megestrol acetate. Naturally occurring glucocorticoids are often used in medicine such a...

In this paper, we study novel variants of the well-known two-echelon vehicle routing problem in which a truck works on first echelon to transport parcels and fleet drones intermediate depots while second echelon, are used deliver from customers. The objective is minimize completion time instead transportation cost as classical problems. Depending context, drone can be launched at an depot once ...

The CO2 emission of transportation is significantly reduced by the employment green vehicles to existing vehicle fleet organizations. This paper intends optimize composition conventional and for a logistics distribution problem operating under carbon cap imposed government. underlying involves product delivery starting from single depot geographically distributed customers. occurs within specif...

UNLABELLED Ligand Depot is an integrated data resource for finding information about small molecules bound to proteins and nucleic acids. The initial release (version 1.0, November, 2003) focuses on providing chemical and structural information for small molecules found as part of the structures deposited in the Protein Data Bank. Ligand Depot accepts keyword-based queries and also provides a g...

Hormonal deprivation therapy is well established for the treatment of locally advanced and metastatic prostate cancer, as well as the adjuvant treatment of some patients with localized disease. Long-acting gonadotropin releasing hormone (GnRH) agonists have become a mainstay of androgen deprivation therapy, due to their efficacy, tolerability, and convenience of use. One-month, 3-month, and 4-m...