A derivative spectrophotometry method was developed to determine enalapril, hydrochlorothiazide, candesartan and walsartan in complex antihypertensive drugs. The pharmaceutical preparations containing hydrochlorothiazide and one of the angiotensin convertase inhibitors were investigated. It was found that the developed method enables the constituents of the investigated drugs to be determined d...

Two-component mixtures of cefsulodin and clavulanic acid were analysed by a first-derivative spectrophotometric method using a zero-crossing technique of measurement. The relative ease offered by this derivative technique for the quantification of these drugs, with closely overlapping spectral bands, was clearly demonstrated. As the absorption band of clavulanic acid closely overlaps with that ...

A first derivative spectrophotometric (D) and derivative ratio (1DD) methods were utilized to determine raubasine (I) and almitrine dismesylate respectively using methanol as a solvent. A linear relationship was obtained in the range from 6-20 μg ml raubasine for the (D) method and 1024 μg ml almitrine dismesylate for the (DD) method. By applying the proposed methods, it was possible to determi...

A poly(vinyl chloride) membrane based on a new a-dioxime derivative as membrane carrier was prepared andinvestigated as a Cr(III) selective electrode. The electrode exhibits a good potentiometric response for Cr(III)over a wide concentration range 1.0 x 10-6 to 1.0 x 10-1 M with a slope 19.5+0.5 mV/decade and low detectionlimit of 8.9 x 10-7 M. It has a fast response time < 15 s. The best perfo...

The present work describes three spectrophotometric methods for determining two phytoconstituent berberine hydrochloride and eugenol in formulated gels: simultaneous equation method, absorbance correction, zero-crossing derivative method. In the at 263 nm 280 correction method 345 were measured applied to their respective estimation of phosphate buffer emulgel. amplitudes first spectra 252.5 26...

The relevance of this study stems from the need for alignment test methods used identification and assay anthracene derivatives in herbal preparations medicinal products. aim was to analyse Russian international quality standards identify most specific sensitive that could be medicines containing derivatives. comparative analysis requirements Identification , Determination major classes bioacti...

Fourier transform infrared spectroscopy (FTIR) combined with multivariate calibration of partial least square (PLS) was developed and optimized for the analysis of Nigella seed oil (NSO) in binary and ternary mixtures with corn oil (CO) and soybean oil (SO). Based on PLS modeling performed, quantitative analysis of NSO in binary mixtures with CO carried out using the second derivative FTIR spec...

A procedure for simultaneous determination of metoprolol and hydrochlorothiazide in tablets by employing derivative spectrophotometry, "zero-crossing" method was developed. The third order derivative absorption spectra at lambda approximately 281 nm were used for metoprolol and the first order derivative spectra at lambda approximately 282 nm were used for hydrochlorothiazide. No interferences ...

Three methods are presented for simultaneous determination of ibuprofen and paracetamol without previous separation. The first method depends on first derivative UV spectrophotometry, with zero-crossing measurement. The first derivative amplitudes at 230 and 290 nm were selected for the assay of ibuprofen and paracetamol, respectively. The second method depends on first derivative of the ratio-...