The title compound, Rb+·H3CN2O-, has been crystallized in liquid ammonia as a reaction product of the reductive ammonolysis of the natural compound streptozocin. Elemental rubidium was used as reduction agent as it is soluble in liquid ammonia, forming a blue solution. Reductive bond cleavage in biogenic materials under kinetically controlled conditions offers a new approach to gain access to s...

Whitfeld and Markham (1) described a method for the stepwise degradation of polyribonucleotides which involved oxidation of the vicinal hydroxyl groups of the terminal nucleoside residue to a dialdehyde by means of periodate, followed by treatment with glycine at pH 10.5 to remove the terminal base. In this way they converted GpC to 3’-GNP and cytosine. A similar procedure was applied to 5’-AMP...

(+)-Ryanodine is a natural product modulator of ryanodine receptors, important intracellular calcium ion channels that play a critical role in signal transduction leading to muscle movement and synaptic transmission. Chemical derivatization of (+)-ryanodine has demonstrated that certain peripheral structural modifications can alter its pharmacology, and that the pyrrole-2-carboxylate ester is c...

The cleavage and addition of ortho C-H bonds in various aromatic compounds such as ketones, esters, imines, imidates, nitrile, and aldehydes to olefins and acetlylenes can be achieved catalytically with the aid of ruthenium catalysts. The reaction is generally highly efficient and useful in synthetic methods. The coordination to the metal center by a heteroatom in directing groups such as carbo...

Since hypervalent twist followed by reductive elimination is a general reaction pattern for iodine reagents, mechanistic studies about the step could provide significant guidance experiments.

An optimized method is presented using liquid-liquid extraction and derivatization for the extraction of iodoacetic acid (IAA) and other haloacetic acids (HAA9) and direct extraction of iodoform (IF) and other trihalomethanes (THM4) from drinking water, followed by detection by gas chromatography with electron capture detection (GC-ECD). A Doehlert experimental design was performed to determine...

Graphite reacts with potassium to form lamellar compounds of different stoichiometry depending on the precise conditions of the preparation.' The best known is the potassium-graphite intercalation compound of stoichiometry C,K, in which each interlayer space in the graphite is occupied by a layer of potassium atoms, i.e. the so-called 'first stage' intercalate. The well defined three dimensiona...