Ferrocene-derived dicarbaldehydes bearing pro-chiral planes are desymmetrized under the catalysis of chiral N-heterocyclic carbene organic catalysts. The reaction features selective activation and one aldehyde moieties ferrocene derivative while leaving other unit untouched. Our affords enantiomerically enriched planar products obtained that amenable for further transformations. Preliminary app...

The structure of uleine type alkaloids is characterized by the presence a bridged tetracyclic hexahydro-1H-1,5-methanoazocino[4,3-b]indole ring system 1. Various strategies have been developed to access this polycyclic structural motif. We report herein one-step conversion appropriately functionalized 1,3,4-trisubstituted cyclopent-1-ene 1 way an integrated oxidation/reduction/cyclization (iORC...