Seven dog cytochromes p450 (p450s) were heterologously expressed in baculovirus-Sf21 insect cells. Of all enzymes examined, CYP1A1 exhibited high 7-ethoxyresorufin O-deethylase activity (low Km enzyme, 1 microM). CYP2B11 and CYP3A12 effectively catalyzed the N1-demethylation and C3-hydroxylation of diazepam (and its derivatives), whereas CYP3A12 and CYP2D15 catalyzed exclusively the N- and O-de...

OBJECTIVE To describe the epidemiology, patient presentation, and clinical management associated with dextromethorphan (DM) abuse. DATA SOURCES PubMed/Medline search using terms dextromethorphan and abuse through July 2008, bibliographies of selected publications, epidemiology tracking databases. STUDY SELECTION By the authors. DATA EXTRACTION English language-published review articles, c...

The phenomenon of dextromethorphan (dextro) abuse is rife in Indonesia. Several cases indicate the occurrence this abuse. As an example case dextro that occurred Manado, North Sulawesi, a woman with initials IR (25), was found dead hotel room Wanea sub-district, Saturday (09/05/2020) after consuming liquid cough medicine containing dextro. Dextro dextro) On (5/9/2020), (25) District, Sulawesi. ...

The effects of dextromethorphan (DM), a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptors, have been investigated on ethanol withdrawal signs in rats. Ethanol (7.2% v/v) was given to rats in a liquid diet for 16 days. DM (10, 20, and 40 mg/kg) and saline were injected intraperitoneally at the third hour of ethanol withdrawal. DM (40 mg/kg) and ethanol dependent saline were ...