In vertebrates, mutations in Protein O-mannosyltransferase1 (POMT1) or POMT2 are associated with muscular dystrophy due to a requirement for O-linked mannose glycans on the Dystroglycan (Dg) protein. In this study we examine larval body wall muscles of Drosophila mutant for Dg, or RNA interference knockdown for Dg and find defects in muscle attachment, altered muscle contraction, and a change i...

The concept of Koszul differential graded algebra (Koszul DG algebra) is introduced. Koszul DG algebras exist extensively, and have nice properties similar to the classic Koszul algebras. A DG version of the Koszul duality is proved. When the Koszul DG algebra A is AS-regular, the Ext-algebra E of A is Frobenius. In this case, similar to the classical BGG correspondence, there is an equivalence...

The conformation of poly(dG-dC).poly(dG-dC), poly(dG).poly(dC), and calf thymus DNA modified with N-acetoxy-N-2-acetylaminofluorene (N-acetoxy-AAF) was examined by extent of reaction with anti cytidine antibodies. In contrast to modified poly(dG).poly(dC0 and DNA, modified poly(dG-dC).poly (dG-dC) failed to react with the antibodies indicating that the base pairing in this polymer is intact. Th...

CpG-Oligodeoxynucleotide (ODN) has two backbones. Phosphorothioate backbone (PS) shows a strong immunostimulating effect while phosphodiester (PE) shows little in vivo. 3' hexameric deoxyriboguanosine-run (3' dG(6)-run) conjugation to PE CpG-ODN has been reported to enhance immunostimulation and to protect against asthma when injected at the time of sensitization in mice. We evaluated the treat...

Dystroglycan (DG) is a highly versatile cell surface molecule that provides a molecular link between the extracellular matrix (ECM) and the actin-based cytoskeleton. Encoded by a single gene, DG is posttranslationally processed to form -DG, a peripheral protein identified as the cellular receptor for lymphocytic choriomeningitis virus (LCMV) and Lassa fever virus (LFV), and the membrane-spannin...

Activation of the hippocampal dopamine 1-class receptors (D1R and D5R) are implicated in contextual fear conditioning (CFC). However, the specific role of the D1R versus D5R in hippocampal dependent CFC has not been investigated. Generation of D1R- and D5R-specific in situ hybridization probes showed that D1R and D5R mRNA expression was greatest in the dentate gyrus (DG) of the hippocampus. To ...

A Markovian queueing model is considered in which servers of various types work in parallel to process jobs from a number of classes at rates μij that depend on the class, i, and the type, j. The problem of dynamic resource allocation so as to minimize a risk-sensitive criterion is studied in a law-of-large-numbers scaling. Letting Xi(t) denote the number of class-i jobs in the system at time t...

Distributed generation (DG) systems are integral parts in future distribution networks. In this paper, a novel approach integrating crisscross optimization algorithm and Monte Carlo simulation (CSO-MCS) is implemented to solve the optimal DG allocation (ODGA) problem. The feature of applying CSO to address the ODGA problem lies in three interacting operators, namely horizontal crossover, vertic...