نتایج جستجو برای: dhea

تعداد نتایج: 1644  

Journal: :General and comparative endocrinology 2016
H Bobby Fokidis

The secretion of steroids from the adrenal gland is a classic endocrine response to perturbations that can affect homeostasis. During an acute stress response, glucocorticoids (GC), such as corticosterone (CORT), prepare the metabolic physiology and cognitive abilities of an animal in a manner that promotes survival during changing conditions. Although GC functions during stress are well establ...

Journal: :Endocrinology 2005
Fang Chen Kristin Knecht Elizabeth Birzin John Fisher Hilary Wilkinson Marina Mojena Consuelo Tudela Moreno Azriel Schmidt Shun-ichi Harada Leonard P Freedman Alfred A Reszka

Dehydroepiandrosterone (DHEA) exhibits peak adrenal secretion in the fetus at term and around age 30 yr in the adult. Levels then progressively decline, which is associated with decreased levels of testosterone, dihydrotestosterone, and estrogen in peripheral tissues. DHEA supplementation in postmenopausal women increases bone formation and density, an effect mainly attributed to peripheral con...

Journal: :American journal of physiology. Endocrinology and metabolism 1998
M McIntosh D Hausman R Martin G Hausman

The purpose of this study was to determine whether the antiobesity actions of dehydroepiandrosterone (DHEA) are due to an influence on preadipocyte proliferation and/or differentiation in primary cultures of pig and rat stromal-vascular (SV) cells. Pig SV cells were isolated from dorsal subcutaneous adipose tissue of 7-day-old pigs. For the proliferation assays, pig SV cells were grown for 4 da...

Journal: :The journal of sexual medicine 2006
Tsuyoshi Mizuno Satoshi Yotsuyanagi Yasuhiro Nagasaka Mikio Namiki

INTRODUCTION Social stress induces sexual dysfunction and reduces serum testosterone (T) level in rats. Stressful events exert an influence on a variety of behaviors and physiology through hormonal changes. The mechanism of stress-induced sexual dysfunction is unknown. AIM To investigate the role of dehydroepiandrosterone (DHEA) in copulatory behavior induced by social stress in rats. METHO...

Ali Khodadadi, Ali Reza Eftekhari moghadam Ghasem Saki, Masoud Hemadi Zohre Mazaheri

Objective(s): Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy chances in women with diminished ovarian reserve (DOR) and to reduce miscarriage rates by 50–80%. This study, therefore, assesses effects of DHEA on number of retrieved oocytes and meiotic spindles.Materials and Methods: A randomized, prospective, controlled study was conducted on eight groups, four groups of you...

2017
Qiaofei Hu Liming Hong Mingyue Nie Qin Wang Ying Fang Yinmei Dai Yanhong Zhai Shuyu Wang Chenghong Yin Xiaokui Yang

BACKGROUND Diminished ovarian reserve(DOR) is associated with female infertility and poor response to ovarian stimulation. Our objective was to assess the effect of dehydroepiandrosterone(DHEA) on DOR women and to explore whether the improvement of ovarian response after DHEA supplementation was dependent on the expression levels of androgen receptor(AR). METHODS A prospective cohort study wa...

2002
Alvaro Osorio Rafael Vara-Thorbeck Jorge Rosell Esperanza Ortega

We selected 38 patients scheduled for cholecystectomy and studied their serum concentrations of dehydroepiandrosterone (DHEA) and growth axis hormones [growth hormone/insulin-like growth factor-1 (GH/IGF-1)]. We aimed to determine whether alterations in these concentrations resulted from surgical stress or, on the contrary, preceded surgery and were themselves a cause of chronic diseases that r...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2007
Krisztina Kohalmy Viola Tamási László Kóbori Eniko Sárváry Jean-Marc Pascussi Pálma Porrogi Damjana Rozman Russell A Prough Urs A Meyer Katalin Monostory

Dehydroepiandrosterone (DHEA), the major precursor of androgens and estrogens, has several beneficial effects on the immune system, on memory function, and in modulating the effects of diabetes, obesity, and chemical carcinogenesis. Treatment of rats with DHEA influences expression of cytochrome P450 (P450) genes, including peroxisome proliferator-activated receptor alpha (PPAR alpha)- and preg...

Journal: :American journal of physiology. Endocrinology and metabolism 2008
Koji Sato Motoyuki Iemitsu Katsuji Aizawa Ryuichi Ajisaka

Circulating dehydroepiandrosterone (DHEA) is converted to testosterone or estrogen in the target tissues. Recently, we demonstrated that skeletal muscles are capable of locally synthesizing circulating DHEA to testosterone and estrogen. Furthermore, testosterone is converted to 5alpha-dihydrotestosterone (DHT) by 5alpha-reductase and exerts biophysiological actions through binding to androgen r...

2014
Bei Xu Zhou Li Jing Yue Lei Jin Yufeng Li Jihui Ai Hanwang Zhang Guijin Zhu

BACKGROUND Dehydroepiandrosterone (DHEA) is now widely used as an adjuvant to IVF treatment protocols in poor responders. However, clinical evidence for DHEA on improvement of ovarian response and IVF outcome is still limited, the validity of the results of the earlier studies, especially the varied inclusion criteria, is a subject of debate. Recently, the ESHRE Working Group developed a new de...

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