Diabetic foot ulcers remain one of the most serious complications of diabetes. Peak plantar pressure (PPP) and peak pressure gradient (PPG) during walking have been shown to be associated with the development of diabetic foot ulcers. To gain further insight into the mechanical etiology of diabetic foot ulcers, examination of the pressure gradient angle (PGA) has been recently proposed. The PGA ...

Normal subjects and diabetic patients with and without food ulcers have been studied using an apparatus which measures the loads on the foot during walking. Diabetic patients have alterations in loading which show as a lateral shift of the highest maximum load on the forefoot and a decrease in the load carried by the toes. There is a significant progression of these changes between normal subje...

This historical perspective highlights some of the pioneers, milestones, teams, and system changes that have had a major impact on management of the diabetic foot during the past 100 years. In 1934, American diabetologist Elliott P. Joslin noted that mortality from diabetic coma had fallen from 60% to 5% after the introduction of insulin, yet deaths from diabetic gangrene of the lower extremity...

This study aimed to evaluate the impact of foot problems on health-related quality of life (HRQoL) in patients with diabetes in Malaysia. Short-Form 36 (SF-36) questionnaire was used to assess the HRQoL of 140 diabetic patients with foot problems attending outpatient diabetic foot clinic in a tertiary hospital, University Malaya Medical Centre. Their HRQoL were compared with 134 diabetic patien...

BACKGROUND Peripheral neuropathy is a major contributor to diabetic foot complications including ulceration, sepsis and limb loss. The aim of this study was to document the frequency of this previously undocumented clinical marker of peripheral neuropathy, the "slipping slipper sign" (SSS), characterised by unrecognised loss of slippers from one's feet while walking, and to compare it with trad...

Dr Paul Brand was the first to widely use Total Contact Casting (TCC) in the mid 1960’s to offload the insensate foot in Hansen’s disease (Sinacore et al, 1987). It has since been identified as a ‘Gold Standard’ for offloading diabetic foot ulceration within the diabetic foot-care community (Boulton, 2004).

AIMS/HYPOTHESIS Topical application of CTGF/CCN2 to rodent diabetic and control wounds was examined. In parallel research, correlation of CTGF wound fluid levels with healing rate in human diabetic foot ulcers was undertaken. METHODS Full thickness cutaneous wounds in diabetic and nondiabetic control rats were treated topically with 1 μg rhCTGF or vehicle alone, on 2 consecutive days. Wound h...

Diabetes mellitus is a disease of complications and Diabetic Foot Syndrome is an important problem confronting society and health professionals. In USA one in four diabetics sustains foot ulcer and 40% of them lose their feet [1]. It accounts for 70% of non-traumatic amputations. In Joslin Diabetes Clinic, 25% admissions are due to foot ulcers. In Indian scene, the data is limited. In the study...