OBJECTIVE To understand the impact of family structure on the metabolic control of children with diabetes, we posed two research questions: 1) what are the differences in sociodemographic, family, and community factors between single-mother and two-parent families of diabetic children? and 2) to what extent do these psychosocial factors predict metabolic control among diabetic children from sin...

OBJECTIVE To evaluate and compare the levels of α-tocopherol in colostrum and in the serum of healthy and diabetic mothers. METHODS This cross-sectional study enrolled 51 volunteer mothers, 20 with the diagnosis of gestational diabetes mellitus and 31 without associated diseases. Serum and colostrum samples were collected in fasting in the immediate postpartum period and α-tocopherol was anal...

BACKGROUND Arachidonic acid (AA; C20∶4 n-6) and docosahexaenoic acid (DHA; C22∶6 n-3) are important long-chain polyunsaturated fatty acids (LC-PUFA) in maintaining pancreatic beta-cell structure and function. Newborns of gestational diabetic mothers are more susceptible to the development of type 2 diabetes in adulthood. It is not known whether low circulating AA or DHA is involved in perinatal...

BACKGROUND Maternal diabetes affects the developing fetal cardiovascular system. Newborn offspring of diabetic mothers can have a transient cardiomyopathy. We hypothesized that cardiomyopathic remodeling is associated with activation of the mitogen activated protein kinase (MAPK) signaling and apoptotic pathways. METHODS To evaluate the effects of moderate and severe maternal hyperglycemia, p...

Maternal complications Early in pregnancy, women with diabetes have an increased rate of abortion (Lorber, Before the discovery of insulin, few women with diabetes became pregnant. Among those who did, the maternal mortality rate was 50% with minimal chance of a live fetus (Parker, 1996). By the late 1930s the perinatal mortality rate had decreased to 40%. Perinatal mortality was thought to be ...

OBJECTIVES Coping with stress plays a vital role in the adjustment of adolescents with diabetes. The majority of studies in this area leave out the control group, limiting their power to make inferences about specificity vs. similarity of coping strategies used by these adolescents. The aims of this study were: (1) To compare coping strategies in adolescents with diabetes and healthy adolescent...

OBJECTIVE To assess the association of anthropometric measurements with neonatal complications in macrosomic newborns of non-diabetic mothers. DESIGN Retrospective cohort study. PATIENTS All liveborn, singleton, full term newborns with birth weight ≥4000 g born to non-diabetic mothers at a tertiary medical centre in 1995-2005 (n=2766, study group) were matched to the next born, healthy, ful...

Background: Due to little attention to the combined effect of diabetes and pregnancy on mother an infant’s microelements in literatures. This study aimed to compare newborns growth parameters, Apgar score, the cord blood zinc, magnesium, calcium and phosphor between pregnant women with and without gestational diabetes mellitus. Materials and Methods: This prospective cohort study was conducted ...

OBJECTIVE Alterations in maternal lipid metabolism could affect fetal programming and the susceptibility for atherosclerosis in the offspring; therefore, we studied differences in lipid profiles of pregnant women with type 1 and type 2 diabetes. RESEARCH DESIGN AND METHODS A total of 173 diabetic pregnancies were studied prior to conception (V0), at each trimester (V1-V3), and after delivery ...

In 1949, Priscilla White published "Pregnancy Complicating Diabetes," which described the results and implications of a fifteen-year study about pregnant diabetic women. Published in the American Journal of Medicine, the article details possible causes of and ways to prevent the high fetal mortality rate associated with pregnant diabetic women. Diabetes is a disease in which the body's ability ...