Glomerular filtration rate was measured from the plasma disappearance curve after a single injection of sodium (125)I-diatrizoate. A therapeutic dose of aspirin in 13 subjects produced a mean fall in glomerular filtration rate of 10.5%.

FUNDAMENTALS American tegumentary leishmaniasis (ATL) treatment remains a challenge, since most available drugs are injectable and only a small number of comparative, randomized clinical trials have been performed to support their use. Moreover, treatment outcome may depend on the causative species of Leishmania. OBJECTIVES To evaluate and compare the efficacy and tolerability of meglumine an...

A case of a pediatric patient with a recurrent single lesion, four months after finishing treatment for seven lesions of cutaneous leishmaniasis with intramuscular meglumine antimoniate. Once the recurrence was confirmed by direct visualization of amastigotes, the decision taken was to repeat treatment with 1 cc of intralesional meglumine antimoniate, with a uniform distribution inside the lesi...

BACKGROUND Pentavalent antimonials (Sb5) and miltefosine are the first-line drugs for treating cutaneous leishmaniasis in Colombia; however, toxicity and treatment duration negatively impact compliance and cost, justifying an active search for better therapeutic options. We compared the efficacy and safety of thermotherapy and meglumine antimoniate for the treatment of cutaneous leishmaniasis i...

pentavalent antimonials are still the first drug of choice for the treatment of cutaneous leishmaniasis (cl). like other treatments, they can cause adverse reactions including musculoskeletal pain , gastrointestinal disturbances, and mild to moderate headaches. in this paper, we report the first case of an infant who developed acute urticaria after her mother’s parenteral use of meglumine antim...

OBJECTIVES To prospectively compare in healthy rats the effect of multiple injections of macrocyclic (gadoterate meglumine) and linear (gadodiamide) gadolinium-based contrast agents (GBCAs) on T1-weighted signal intensity in the deep cerebellar nuclei (DCN), including the dentate nucleus. MATERIALS AND METHODS Healthy rats (n = 7/group) received 20 intravenous injections of 0.6 mmol of gadoli...

Subjective estimates of the angiographic severity of coronary artery stenoses show variability and inaccuracy. We therefore tested the accuracy of a newly developed computerized image analysis system for quantitating vessel diameter from cineangiograms. Fourteen cylindrical phantoms of known diameter were filled with contrast medium and filmed over a wide range of clinically relevant radiograph...

Meconium ileus equivalent is one of the lesser known manifestations of cystic fibrosis, and occurs most often in older patients. With the improved overall survival of patients with cystic fibrosis, one would expect to see this condition more often in the future. Of 53 patients attending our cystic fibrosis clinic for adolescents and adults, eight had experienced a total of 25 episodes of meconi...