In chronic myelogenous leukemia (CML), the development of chromosomal abnormalities in addition to the Philadelphia chromosome (clonal evolution) is considered by many to be a feature of accelerated phase (AP). Imatinib mesylate (STI571), a selective inhibitor of the Bcr-Abl tyrosine kinase, has significant activity in AP CML. As clonal evolution could allow Bcr-Abl independent proliferation, w...

In the current study, the effects of ethanol (EtOH) on toxicokinetics of methamphetamine (MA) and its metabolite amphetamine (AP) were investigated. A single dose of MA hydrochloride at 15 mg/Kg was given intragastrically, either alone (MA group; n = 8) or in conjunction with 3 g/Kg EtOH (MA+EtOH group; n = 8) to rabbits. In placebo group, normal saline only was given (placebo group; n = 4). Pl...

Background: Propagation of race has been threatening by infertility which is a widespread impediment for human. About 50% of infertilities accounts for male Sexual dysfunction. Medicinal plants as a traditional treatment play a great role in remedies due to their accessibility, availability and affordability. Anacycluspyrethrum (AP) roots commonly known as pllitorybelongs. Tribulusterrestris (T...

in the current study, the effects of ethanol (etoh) on toxicokinetics of methamphetamine (ma) and its metabolite amphetamine (ap) were investigated. a single dose of ma hydrochloride at 15 mg/kg was given intragastrically, either alone (ma group; n = 8) or in conjunction with 3 g/kg etoh (ma+etoh group; n = 8) to rabbits. in placebo group, normal saline only was given (placebo group; n = 4). pl...

Clathrin associated adaptor protein is involved in endocytosis at the plasma membrane (AP-2) and protein sorting at the Golgi membrane (AP-1). There is a great deal of information available on the structure, function and binding characteristics of AP-2, however, there is little quantitative data on the AP-2 distribution at the membrane. Image correlation spectroscopy is a technique which yields...

Aminopyridines (2-AP, 3-AP, and 4-AP) selectively block K channels of squid axon membranes in a manner dependent upon the membrane potential and the duration and frequency of voltage clamp pulses. They are effective when applied to either the internal or the external membrane surface. The steady-state block of K channels by aminopyridines is more complete for low depolarizations, and is gradual...