Status epilepticus (S.E.) is known to lead to a large number of changes in the expression of voltage-dependent ion channels and neurotransmitter receptors. In the present study, we examined whether an episode of S.E. induced by pilocarpine in vivo alters functional properties and expression of voltage-gated Na(+) channels in dentate granule cells (DGCs) of the rat hippocampus. Using patch-clamp...

This paper presents an improved design of voltage controlled oscillator (VCO) utilizing the three differential cell CMOS inverters for forming the ring oscillator. The differential cell reduces the power supply fluctuations impact on the oscillator jitter while the negative feedback from frequency to voltage converter reduces the jitter at high frequencies. Finally the proposed model is designe...

In this study consideration is made of the common mode (CM) behavior of two-stage fully differential amplifiers in voltage feedback connection. In particular, interaction between internal CMFB circuitry and the external feedback network is investigated in order to highlight a possible operating point instability condition, due to the presence of a positive feedback loop. Two alternative CMFB to...

In this paper, we analyze the identifiability properties of a Hodgkin-Huxley (HH) type voltage dependent ion channel model under voltage clamp circumstances. The elimination of the differential variables is performed, and the identifiability of various parameters is analyzed using the differential algebra approach and the algorithm based on the Taylor series expansion of the output. It is shown...

Abstract: In this paper we present a novel static differential ultra low-voltage (ULV) CMOS logic style. Simulated data for the logic style is presented and compared to related ULV logic styles and complementary CMOS gates. The proposed logic style is aimed for high speed serial adders in ultra low-voltage applications. In terms of energy delay product (EDP) the logic style offers a significant...

Low voltage (LV) analog circuit design techniques are addressed in this tutorial. In particular, (i) technology considerations; (ii) transistor model capable to provide performance and power tradeoffs; (iii) low voltage implementation techniques capable to reduce the power supply requirements, such as bulk-driven, floating-gate, and self-cascode MOSFETs; (iv) basic LV building blocks; (v) multi...

Mohamed O. Shaker et al. 175 A new CMOS voltage-controlled fully-differential transconductor is presented. The basic structure of the proposed transconductor is based on a four-MOS transistor cell operating in the triode or saturation region. It achieves a high linearity range of ± 1 V at a 1.5 V supply voltage. The proposed transconductor is used to realize a new fully-differential Gm-C low-pa...

A 200-eV electron beam is incident on an electrode in a laboratory plasma. The emission of secondary electrons produces a region of negative differential resistance in the current-voltage characteristic of the electrode. Spontaneous dynatron oscillations are driven by the negative differential resistance when a resonant circuit is placed in series with the electrode. The instability is driven b...

A new current source for low-voltage applications is proposed. This current source is well suited for biasing differential pairs and source followers. Measured compliance voltage is slightly smaller than that of a single transistor. Its output resistance is a factor of 25 larger than that of a single transistor current source and was measured to be 8 M : The use of the new current source improv...

The whole plant of Biophytum petersianum was extracted with a mixture of water – alcohol (1:1) to evaluate its relaxant effect on aorta rings. In isolated Wistar rat tissue, the hydro-ethanolic extract (0.1; 0.25 and 0.5 mg/ml) non-competitively antagonized calcium chloride and high-K + - induced aorta contractions in a concentration-dependent manner. Moreover, the inhibition of noradr...