BACKGROUND Merkel cell carcinomas are rare neoplasm of neuroendocrine origin, usually observed in elderly people in areas with abundant sunlight, and predominantly located on the head and neck, extremities, and trunk. In many patients, a local recurrence after resection of the primary tumour and even distant metastases can be found. CASE PRESENTATION We report an unusual occurrence of pancrea...

Aims Medullary carcinoma is an uncommon colorectal tumour which appears poorly differentiated histologically. Consequently, it may be confused with adenocarcinoma not otherwise specified (NOS). The principal aim of this study was to review a large series cancers resected at National Health Service (NHS) Teaching Hospital determine how often medullary carcinomas were misclassified . Secondary ai...

following the first report of laryngeal small cell carcinoma in canada in 1972,only 82 cases of this cancer has been reported in the literature untill 2001.this cancer originates from laryngeal neuroendocrine cells.It,s clinical presentation consists of hoarseness,breathing difficulty:and cigarette smoking is the most important risk factor.this type of cancer is mostly presented after 50 years ...

Background Pulmonary neuroendocrine tumors include well-differentiated and poorly differentiated histology for which cell type has proved to be a determinant of survival in many studies. In patients diagnosed with bronchial carcinoid large carcinoma (LCNEC), surgery is the treatment choice even case locally advanced disease lymph node involvement. Methods We retrospectively an...

ee front matter & 2005 dip.2005.10.009 719 2613; fax: +1 818 71 ess: lester.d.thompson@ Summary Malignant neoplasms of the sinonasal tract encompass a wide variety of epithelial, lymphoid and mesenchymal tumours. The separation and classification of epithelial or neuroepithelial tumours is sometimes challenging, especially when treatment and prognosis are different. Squamous cell carcinoma, ker...

We reviewed 11 cases of primary thymic neuroendocrine carcinomas with combined features ranging from well-differentiated to poorly differentiated neuroendocrine carcinoma. For 3 asymptomatic patients, tumors were discovered during routine examination. Presentation in the other patients was as follows: Cushing syndrome, 2 patients; chest pain, 3 patients; superior vena cava syndrome, 1 patient; ...

There have been very few prospective studies of first-line chemotherapy on advanced gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC). This phase II study assessed the activity and safety of irinotecan plus cisplatin (IP) followed by octreotide long-acting release (LAR) maintenance treatment in advanced GEP-NEC. Forty patients were treated and eighteen patients (45.0%) had a partial res...

Carcinoid tumor of the thymus is a rare neoplasm. It comprises a wide spectrum of lesions ranging from well-differentiated to poorly-differentiated neoplasms. We report a case of anterior mediastinal mass, which is proven to be an atypical thymic carcinoid tumor with a histopathological nature of intermediate-grade moderately-differentiated neuroendocrine carcinoma. We also present the patient’...

Pancreatic neuroendocrine neoplasms (pNENs) are rare tumors accounting for only 1%-2% of all pancreatic tumors. pNENs are pathologically heterogeneous and are categorized into three groups (neuroendocrine tumor: NET G1, NET G2; and neuroendocrine carcinoma: NEC) on the basis of the Ki-67 proliferation index and the mitotic count according to the 2010 World Health Organization (WHO) classificati...

Sorafenib is a multi-kinase inhibitor and a vascular endothelial growth factor (VEGF) inhibitor approved to treat patients with advanced hepatocellular carcinoma, renal cell carcinoma and differentiated thyroid carcinoma. Its most common side effects are asthenia/fatigue, skin toxicity, diarrhea and arterial hypertension. Reported respiratory adverse reactions include dyspnea, cough, pleural ef...