Restrictions in neuronal fate occur during the transition from a multipotential to a postmitotic cell. This and later steps in neuronal differentiation are determined by extracellular signals. We report that basic fibroblast growth factor is mitogenic for stem cells and is a differentiation factor for calbindin-expressing hippocampal neurons. The neurotrophin NT-3 is a differentiation factor fo...

Cell cycle exit is required for proper differentiation in most cells and is critical for normal development, tissue homeostasis, and tumor suppression. However, the mechanisms that link cell cycle exit with differentiation remain poorly understood. Here, we show that the master melanocyte differentiation factor, microphthalmia transcription factor (MITF), regulates cell cycle exit by activating...

The physiologic program of macrophage differentiation normally proceeds in a coordinated manner in response to several different growth factors. Although the utilization of common receptor subunits may explain in part overlapping biologic functions, mechanisms by which unique actions are mediated remain obscure. We examined growth factor-induced macrophage differentiation in M1 leukemia cells t...

Nontransformed 3T3 T mesenchymal/proadipocyte stem cells can be readily induced to differentiate, yet previous work has shown that 3T3 T cells that are spontaneously or virally transformed not only lose their normal growth control mechanisms but also lose the ability to differentiate. Loss of growth control can be due to autocrine mechanisms in some transformed cells, but the mechanisms involve...

Mouse myeboidleukemic Ml cells were induced to differen tiate in vitro into macrophages and granubocytes by various inducers, such as differentiation stimulating factor (D-factor) in conditioned medium of mouse peritoneal macrophages and mouse embryo cells, dexamethasone, bipopolysaccharide, and polyinosinic acid. Interferon, which was prepared from Ml cells treated with copolymer of pobyinosin...

Abstract This study analyzes the psychometric properties of Differentiation Self Scale-Revised (DSS-R), an instrument assessing differentiation self Spanish adults through dimensions I Position, Emotional Reactivity, Fusion with Others and Cutoff, a new dimension, Dominance over Others. In Study 1, carried out 1445 subjects, exploratory factor analysis was performed one half participants, confi...

the families of tgf-β proteins are the most important growth factors in the ovary for growth and differentiation of early ovarian follicles. three related oocyte-derived members of the transforming growth factor-β superfamily namely growth differentiation factor 9 (gdf9), bmp15 and bmpr-ib have been shown to be essential for follicular growth and ovulation. different mutations in the gdf9 gene ...

Mouse myeloid leukemic MI cells can be induced to differentiate into mature macrophages and granulocytes by differentiation-stimulating factor (D-factor) in conditioned medium of mouse peritoneal macrophages. Double-stranded RNA's, such as the copolymers of polyinosinic and polycytidylic acids and polyadenylic and polyuridylic acids, could not alone induce differentiation of the cells, but enha...