Sporadic Creutzfeldt-Jakob disease is considered primarily a disease of grey matter, although the extent of white matter involvement has not been well described. We used diffusion tensor imaging to study the white matter in sporadic Creutzfeldt-Jakob disease compared to healthy control subjects and to correlated magnetic resonance imaging findings with histopathology. Twenty-six patients with s...

The integrity of white matter, as measured in vivo with diffusion tensor imaging (DTI), is disrupted in normal aging. A current consensus is that in adults advancing age affects anterior brain regions disproportionately more than posterior regions; however, the mainstay of studies supporting this anterior-posterior gradient is based primarily on measures of the corpus callosum. Using our quanti...

OBJECTIVE/BACKGROUND The majority of multiple sclerosis patients experience impaired walking ability, which impacts quality of life. Timed 25-foot walk is commonly used to gauge gait impairment but results can be broadly variable. Objective biological markers that correlate closely with patients' disability are needed. Diffusion tensor imaging, quantifying fiber tract integrity, might provide s...

Recent studies have shown that the Cu/cap layer interface is the dominant diffusion path for electromigration (EM) in Cu interconnects, making it important to develop effective methods to evaluate the effect of passivation layer on interfacial mass transport and EM lifetime for Cu interconnects. This work shows that a set of isothermal stress relaxation tests together with appropriate modeling ...

BACKGROUND Abnormal diffusion parameters are reported in specific brain regions and white matter tracts in bipolar disorder. AIMS To investigate whether these abnormalities are generalised, and thus evident in large regions of white matter. METHOD Diffusion parameters were measured at several regions in the corpus callosum and in deep/periventricular white matter in 28 currently euthymic pa...

Solid phase diffusivity Ds is a key parameter in Lithium-Ion cell models because solid phase diffusion typically dominates the voltage transients. The Galvanostatic Intermittent Titration Technique (GITT) is easy to implement and universally accepted as the standard for diffusivity measurement, but the accuracy of GITT diffusivity measurement is unknown. This paper develops a Least Squares GITT...

Diffusive eddy closure theory for estimating the poleward heat flux is reexamined and tested in the context of a two-layer homogeneous model. Consideration of the inverse energy cascade induced by baroclinic turbulence on the b plane leads to an expression for diffusivity in terms of the kinetic energy dissipation and the b effect. A key step in the closure is the identification of this diffusi...

Molecular dynamics simulations of the diffusion of trans-2-butene in zeolite type MEL at 623 K have revealed an initial increase of the self-diffusivity with increasing loading, in contrast to simulation data collected for the other butene isomers. This is usually the signature of repulsive guest-guest interactions. At higher loadings, however, the concentration dependence was shown to decrease...