Center for Systems Biomedicine, Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA Department of Neurology, Martinos Center for Biomedical...

Alcohol is one of the most common causes of liver disease after the Hepatitis C Virus (HCV). 80% of deaths from liver disease, 60% of cirrhosis and 50% of deaths from cirrhosis are alcohol related. In addition, the association between alcoholdependance and HCV infection is the primary cause of hepatocellular carcinoma (HCC) [4, 5]. With the introduction of new Direct-Acting Antivirals (DDAs) du...

Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (M.S., T.N., S.A.M., K.T., R.V.B., R.T.J.); Biostatistics and Data Management Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (D.J.V.); Peptide Research Laboratories, Department of Medicine, Tulane University Health Sciences Center, New...

background: the nigella sativa l. seeds have been used as herbal medicine in several countries for the treatment and prevention of a wide range of diseases like cough and bronchial asthma, headache, nasal congestion, toothaches, intestinal worm, menstrual disorder, digestive abnormality, and impotence. objective: the aim of this review was to collect updated available data focused on the pharma...

INTRODUCTION In mammalian pancreatic cells, the pancreatic secretory trypsin inhibitor (PSTI) prevents the premature activation of digestive enzymes and thus plays an important role in a protective mechanism against tissue destruction by autophagy, a process which may ultimately cause diseases such as pancreatitis and pancreatic cancer. Insects, however, lack a pancreas and so far no PSTI-like ...