We investigated the mechanism whereby ions cross dihydropyridinesensitive (L-type) Ca channels in guinea pig ventricular myocytes. At the singlechannel level, we found no evidence o f an anomalous mole-fraction effect like that reported previously for whole-cell currents in mixtures o f Ba and Ca. With the total concentration o f Ba + Ca kept constant at 10 (or 110) mM, neither conductance nor ...

To investigate autoantibodies related to excitation-contraction (E-C) coupling in patients with myasthenia gravis (MG), we developed a novel method to detect autoantibodies against dihydropyridine receptor (DHPR). Using this method, we detected DHPR antibody in 37% (11 out of 30) of MG patients with thymoma. Antibodies were not detected in normal nor disease controls. The titer of DHPR antibodi...

the present study reports a microwave-assisted method for the synthesis of twelve novel tricyclic 1,4-dihydropyridine derivatives in which dimethyl-substituted cyclohexane and / or tetrahydrothiophene rings are fused to the dhp ring. the structures of the compounds were confirmed by spectral methods and elemental analysis. the potassium channel opening effects of the compounds were determined o...

zrp2o7 nanoparticles (nps) as an efficient catalyst have been used for the preparation of 1,6-diamino-2- oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile derivatives via one-pot coupling of hyrazine hydrate, ethyl cyanoacetate, malononitrile and aromatic aldehydes under reflux conditions in ethanol. using this method we obtained low reaction times, easy isolation of the targeted molecules, e...

In the title compound, C(18)H(22)N(2)O(4), the dihedral angle between the two rings is 87.90 (6)°. The mean devation of the atoms in the dihydropyridine plane is 0.082 (3) Å. In the crystal, mol-ecules are linked by inter-molecular N-H⋯N hydrogen bonds, generating chains.

1,4 dihydropyridines (e.g. nifedipine) undoubtedly are among the most powerful calcium antagonists. They act by blocking Ca channels when bound from the outside of the sarcolemma on a proteinic receptor (Glossmann et al. 1982). From inotropic measurements it had been supposed that a new dihydropyridine compound (BAY-K 8644, Methyl