Acne is caused by the action of dihydrotestosterone, derived from endogenous and exogenous precursors, likely acting synergistically with insulin-like growth factor-1. These sources and interactions are discussed. Both a mechanism of action and recommended dietary changes that limit ingestion and production of these hormones are proposed.

We assessed androgen receptor (AR) expression in osteoclasts in vitro and in situ. Rat multinucleated osteoclasts expressed detectable AR protein in situ, and AR mRNA was detected in mouse and human derived osteoclast-like cells in vitro. Dihydrotestosterone treatment did not affect human osteoclast-like cell formation or resorption in vitro.

It is suspected that prenatal hormones can affect maternal care, which has important implications for the neurological development of pups. To determine if the altered hormone levels affected maternal care, pregnant dams were exposed to sex hormones and maternal care behavior was quantified and analyzed. Pregnant dams were exposed to corn oil (solvent control), 50ug/kg of estradiol benzoate, or...

Cells from a human prostatic adenocarcinoma cell line (PC3) were maintained in M199 medium, with and without 5% Bobby calf serum, to examine aspects of cellular zinc metab olism. Cultures contained 0.5 to 1.0 x 106 cells/dish. En hanced 65Zn accumulation in response to dexamethasone was observed after 24 hr in culture. The rate of efflux of accumu lated 65Zn was not influenced by this hormone. ...

The presence of aromatase activity, estrogen receptors, and estrogenic responsiveness in MCF-7 human breast cancer cells has allowed this cell line to be used as a unique in vitro system for investigating the biological activities of potentially therapeutic aromatase inhibitors. We now report the results of studies which have examined the cytotoxicity, antiaromatase, and intrinsic estrogenic ac...

The medial nucleus of the amygdala (Me) processes both chemosensory and hormonal input. In the male Syrian hamster the integrity of this nucleus is essential for normal reproductive behavior. To determine if gonadal steroids modulate neuronal structure in this nucleus, the morphology of Golgi-stained neurons in the anterior and posterior regions of Me were compared in castrated and reproductive...

Sertoli cells play a central role in the control and maintenance of spermatogenesis by secreting growth factors, in response to hormonal stimulation, that participate in the paracrine regulation of this process. In this study, we investigated how the hormonal regulation of spermatogenesis modulates 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB) isozyme expression in two mouse sper...

The incidence of hepatocellular carcinoma (HCC) is more prevalent in males than in females. 5a-Dihydrotestosterone is the most potent form of androgen and is converted from testosterone by 5a-reductase. The antitumor effect of a 5a-reductase inhibitor (FK143) was evaluated in a rat chemical hepatocarcinogenesis model (Solt-Farber). Male Fischer 344 rats were used in three groups: (a) control gr...