BACKGROUND Despite considerable mortality, population-based prognostic factors for childhood dilated cardiomyopathy are lacking. METHODS AND RESULTS A population-based cohort study was undertaken of all children in Australia who presented with cardiomyopathy at age 0 to 10 years between January 1, 1987, and December 31, 1996. A single cardiologist analyzed all cardiac investigations, and a si...

BACKGROUND AND OBJECTIVES: Ambulatory blood pressure monitoring is recommended for several diseases in childhood; however, there are no reports about its use in the monitoring of children with dilated cardiomyopathy so far. We evaluated the pattern of ambulatory blood pressure monitoring in children with dilated cardiomyopathy and correlated it to height, weight, and body mass index. METHODS: P...

Dilated cardiomyopathy (DCM) is the most common cause of heart failure and cardiac transplantation, and is among the most common diagnoses requiring hospitalization in North America. Approximately 4.7 million people in the United States have heart failure, and approximately 550,000 new cases are diagnosed annually (1). The 5-year mortality rate among patients with heart failure is close to 50% ...

A case of idiopathic dilated cardiomyopathy (DCM) that is likely to be associated with LMNA mutation Arg190Pro in a heterozygote is described. The features of DCM in the patient were conduction disorders, cardiac arrhythmias, progressive heart failure and minor musculoskeletal disturbances. We consider that the mutation Arg190Pro contributes to the formation of a weak nuclear lamina and diminis...

Acromegaly is a rare condition with an approximate incidence of 3-4 new cases per million per year and occurs as a result of excess secretion of growth hormone (GH). It is associated with several cardiovascular manifestations of which dilated cardiomyopathy with systolic and diastolic dysfunction is relatively rare but associated with increased mortality. There are very few documented cases of ...

The dynamics between mitral anulus motion, and, thus, motion of the base of the heart, and filling of the left atrium and ventricle were studied by Doppler echocardiography in 12 normal subjects and 28 patients with dilated cardiomyopathy. The normal motion of the mitral anulus is associated with two phases of inflow from the pulmonary veins. The first phase (J) of pulmonary venous inflow occur...

ilated cardiomyopathy (DCM), characterized by left venricular dilation and systolic dysfunction, is the most comon form of heart muscle disease, comprising 60% of the ases of identified cardiomyopathies (1). The disorder is linically heterogeneous, ranging from affected individuals ith clinical presentations of severe symptoms, including eart failure, sudden death, or resuscitated sudden death,...

In majority of the cases familial dilated cardiomyopathy (DCM) is inherited in an autosomal dominant manner. In rare instances, this condition is inherited in an autosomal recessive pattern. In other rare cases, DCM can be inherited in an Xlinked pattern. Establishing a genetic diagnosis confirms or modifies the clinical diagnosis and enables disease specific estimates on prognostics and treatm...

Compared with other cardiovascular diseases, heart muscle disease (cardiomyopathy) is relatively rare. In its most common form, the disease accounts for only 50,000 new cases in the United States each year, while the annual number of stroke cases, for example, reaches 500,000. Unlike many other cardiovascular disorders that tend to affect the elderly, cardiomyopathy commonly occurs in the young...