To cite: Toescu SM, Kennon S, Stevens H. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013201536 DESCRIPTION A 64-year-old man presented with a 12-month history of angina. Following coronary angiography he underwent percutaneous coronary intervention with deployment of drug-eluting stents to the left anterior descending and main diagonal branch. He was discharg...

BACKGROUND Calcium antagonists are a first-line treatment for hypertension. The effectiveness of diltiazem, a non-dihydropyridine calcium antagonist, in reducing cardiovascular morbidity or mortality is unclear. We compared the effects of diltiazem with that of diuretics, beta-blockers, or both on cardiovascular morbidity and mortality in hypertensive patients. METHODS In a prospective, rando...

Herbal remedies for skin care with antibacterial and antifungal activities are prepared from a variety of plant parts such as leaves, stem, root, bark and fruits. These medicines are administered topically and may be applied in the form of cream, lotion, soap, sap, solvent extract and ointment, and have been established to possess antimicrobial properties[1]. The delivery of drugs through the s...

BACKGROUND An aerosol foam formulation of fixed combination calcipotriene 0.005% (as hydrate; Cal) plus betamethasone dipropionate 0.064% (BD) was developed to improve psoriasis treatment. OBJECTIVES To compare the efficacy and safety of Cal/BD aerosol foam with Cal/BD ointment after 4 weeks. METHODS In this Phase II, multicenter, investigator-blind, 4-week trial, adult patients with psoria...

Salicylic acid was applied topically to the skin of rabbits and humans in order to study the pharmacokinetics of percutaneous absorption, and the effects of formulation and application variables on the rate and extent of absorption. Drug samples incorporated into hydrophilic ointment (USP} and hydrophilic ointment containing 10% urea, were applied to the shaved abdominal areas of female New Zea...

A new high-performance liquid chromatographic method has been developed for the determination of diltiazem in human cardiac tissue. Tissue samples are homogenized and digested with trypsin solution. Diltiazem and the internal standard are extracted with acetone. The extract is evaporated to dryness and reconstituted in potassium phosphate buffer. Samples are then cleaned up with solid-phase ext...

The authors would like to thank Professor Halil Dogan (Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey) for informing them of the following error. The following sentence within the last paragraph of the ‘Diltiazem and Atrial Arrhythmias’ section, ‘‘A retrospective study evaluated 77 patients with supraventricular tachycardia treated with oral adenosine or intravenous di...