We investigated the effects of mesenchymal stem cells (MSCs) on wound healing using a three-dimensional (3D) collagen gel scaffold. Three circular full-thickness skin defects were created on the back of Sprague-Dawley rats. One site was covered with a 3D collagen gel containing 2 × 10(6) MSCs (MSCs+/3D collagen+). Another site was replaced with a 3D collagen gel without MSCs and the third site ...

We present the 3D Video Recorder, a system capable of recording, processing, and playing three–dimensional video from multiple points of view. We first record 2D video streams from several synchronized digital video cameras and store pre-processed images to disk. An off-line processing stage converts these images into a time–varying three– dimensional hierarchical point–based data structure and...

We present a semantics-driven contour tree visualization approach to support exploring and comparing cohort-level brain white matter connectivities. A contour tree is a topological method that stores the nesting relationships of the contours in a scalar field, here a brain water molecule movement measure of factional anisotropy (FA) values. Previous contour tree visualizations have lacked the c...

Three-dimensional (3D) diffuse optical tomography is known to be a nonlinear, ill-posed and sometimes under-determined problem, where regularization is added to the minimization to allow convergence to a unique solution. In this work, a generalized least-squares (GLS) minimization method was implemented, which employs weight matrices for both data-model misfit and optical properties to include ...

Nucleation and propagation of a shear fault is known to be the result of interaction and coalescence of many microcracks. Yet the character and rate of the microcracks' interactions, and their dependence on the three-dimensional stress state are poorly understood. Here we investigate formation of microcracks during sandstone faulting under 3D-polyaxial stress fields by analyzing multi-stationar...