The dimeric hemoglobin isolated from Scapharca inaequivalvis, HbI, is notable for its highly cooperative oxygen binding and for the unusual proximity of its heme groups. We now report that the oxidized protein, an equilibrium mixture of a dimeric high spin aquomet form and a monomeric low spin hemichrome, binds ferrocyanide tightly which allows for internal electron transfer with the heme iron....

s | 79 Abstract Background: Group I metabotropic glutamate receptor (mGluR1 and mGluR5) allosteric modulators are currently being investigated as novel therapeutics for the treatment of neurodevelopmental disorders such as schizophrenia, autism, depression (Cleva and Olive, 2011). Recent evidence suggests that allosteric modulators have adverse pharmacological effects when bound to the monomeri...

s | 79 Abstract Background: Group I metabotropic glutamate receptor (mGluR1 and mGluR5) allosteric modulators are currently being investigated as novel therapeutics for the treatment of neurodevelopmental disorders such as schizophrenia, autism, depression (Cleva and Olive, 2011). Recent evidence suggests that allosteric modulators have adverse pharmacological effects when bound to the monomeri...

N-N Dimeric indolosesquiterpene alkaloids are a class of under-explored architecturally intriguing natural products. Herein, we report the first chemical oxidation approach to asymmetric total syntheses these atropisomeric indolosesquiterpenoids...

We previously isolated a naturally occurring dimer of human placental lactogen (hPL) and showed that it was linked by one or more disulfide bonds. Monomeric hPL is a 191-amino acid peptide with two disulfide bonds, one between residues 54 and 165 and the other between 182 and 189. The present studies were designed to determine the location of the disulfide bonds in dimeric hPL and to relate thi...

We present the dielectric relaxation properties of ferroelectric smectic-A (SmAP F ) phase formed by a mixture bent-shaped dimeric molecules α,ω-bis(4-alkoxyanilinebenzylidene-4′-carbonyloxy)pentanes with different alkyl chain lengths.

Angiopoietin-1 (Ang1), a potential growth factor for therapeutic angiogenesis and vascular stabilization, is known to specifically cluster and activate Tie2 in high oligomeric forms, which is a unique and essential process in this ligand-receptor interaction. However, highly oligomeric native Ang1 and Ang1 variants are difficult to produce, purify, and store in a stable and active form. To over...

Dimeric IgA Abs contribute significantly to the humoral part of the mucosal immune system. However, their potential as immunotherapeutic agent has hardly been explored. In this article, we describe the production, purification, and functional evaluation of recombinant dimeric IgA against the epidermal growth factor receptor. Human joining chain-containing IgA was produced by nonadherent Chinese...

The dUTPase (Dut) enzymes, encoded by almost all free-living organisms and some viruses, prevent the misincorporation of uracil into DNA. We previously proposed that trimeric Duts are regulatory proteins involved in different cellular processes; including the phage-mediated transfer of the Staphylococcus aureus pathogenicity island SaPIbov1. Recently, it has been shown that the structurally unr...