THERE has long been a need in ophthalmology for a pleasant, non-irritant, safe and effective local analgesic, free from such side-effects as pupil dilatation or cycloplegia. The compounds in common use to-day, such as cocaine 4 per cent. (D.D.A.), affect the pupil and desiccate the cornea, and amethocaine (Pantocain, Pontocaine, Tetracain) and related compound amylocaine (Dorsacaine, Phenolaine...

The compound L-valine-3-{8-[(E)-2-[3-methoxyphenyl)ethenyl]-7-methyl-1-propargylxanthine-3-yl}propyl ester hydrochloride (MSX-4) was synthesized as an amino acid ester prodrug of the adenosine A2A receptor antagonist MSX-2. It was found to be stable in artificial gastric acid, but readily cleaved by pig liver esterase.

AIM To assess the effect of semicarbazide hydrochloride (SCZ), the blocker of synthetic enzyme for GABA, on the hypnotic activity of melatonin. METHODS Righting reflex method in mice and electroencephalography (EEG) in rats were used to determine effects of SCZ on sleep and hypnotic activity of melatonin. RESULTS Melatonin displayed a marked hypnotic activity both in righting reflex experim...

Sleep is vital for cardiometabolic health, but a societal shift toward poor sleep is a prominent feature of many modern cultures. Concurrently, factors such as diet and lifestyle have also changed and may mediate the relationship between sleep quality and cardiometabolic health. Objectives were to explore (1) the interrelationship and (2) mediating effect of inflammation, oxidative stress, and ...

w: LF (nu) 67-9 (11 1)* 53-2 (7 3) HF (nu) 32-1 (8 1)* 42-7 (4 9) LF/HF 2-33 (0 88)* 1-28 (0-21) Stage 2 non-REM sleep: LF (nu) 39-9 (13-9) 36-2 (15-5) HF (nu) 60-1 (15-2) 57.3 (11-2) LF/HF 0-84 (0 63) 0-76 (0 48) Stage 3-4 non-REM sleep: LF (nu) 26-9 (11 1) 25-9 (8-6) HF (nu) 73-1 (14 6) 66-2 (11-6) LF/HF 0 47 (0 41) 0-46 (0-32) REM sleep: LF (nu) 56-3 (12 8) 53 2 (16-6) HF (nu) 43 7 (8 3) 41 ...

PURPOSE Two cases of successful desensitization to docetaxel after severe hypersensitivity reactions are reported. SUMMARY Two patients with gynecological malignancies (uterine leiomyosarcoma and ovarian adenocarcinoma) experienced severe hypersensitivity reactions with docetaxel, including flushing, numbness, sharp radiating pain, severe nausea and vomiting, apnea, and unresponsiveness. Both...

A hallmark feature of cognitive aging is a decline in the ability to form new memories. Parallel to these cognitive impairments are marked disruptions in sleep physiology. Despite recent evidence in young adults establishing a role for sleep spindles in restoring hippocampal-dependent memory formation, the possibility that disrupted sleep physiology contributes to age-related decline in hippoca...

We present the results of a detailed study of the thermally assisted-resonant-tunneling relaxation rate of Mn12 acetate as a function of an external, longitudinal magnetic field and find that the data can be fit extremely well to a Lorentzian function. No hint of inhomogeneous broadening is found, even though some is expected from the Mn nuclear hyperfine interaction. This inconsistency implies...

The title compound, C(21)H(18)O(7), is an important inter-mediate in the synthesis of 3-(4-hydroxy-phen-yl)-4-methyl-6-meth-oxy-7-hydroxy-coumarin, which is a nonsteroidal analogue of 2-methoxy-estradiol (2-ME). The substituent benzene ring is not in the same plane as the coumarin ring system, with a dihedral angle of 66.88 (10)°. There are some weak inter-molecular C-H⋯O inter-actions. One car...

Quentin Denost, MD, PhD, y Philippe Rouanet, MD, PhD,z Jean-Luc Faucheron, MD, PhD,§ Yves Panis, MD, PhD,jj Bernard Meunier, MD, Eddy Cotte, MD, PhD,yy Guillaume Meurette, MD, PhD,zz Sylvain Kirzin, MD, PhD,§§ Charles Sabbagh, MD, PhD, jjjj Jèrôme Loriau, MD, PhD, Stèphane Benoist, MD, PhD,yyy Christophe Mariette, MD, PhD,zzz Igor Sielezneff, MD, PhD,§§§ Bernard Lelong, MD, François Mauvais, MD...