نتایج جستجو برای: direct macrocyclization

تعداد نتایج: 425220  

Journal: :Chemical science 2017
Jian Tang Yadong He Hongfei Chen Wangjian Sheng Huan Wang

Cyclic peptides have attracted increasing attention in recent years due to their ability to inhibit protein-protein interactions. Current strategies to prepare cyclic peptides often rely on functional amino acid side chains or the incorporation of unnatural amino acids, thus limiting their structural diversity. Here, we describe the development of a highly versatile peptide macrocyclization str...

2015
Michael Fuchs Alois Fürstner

The important biochemical probe molecule brefeldin A (1) has served as an inspirational target in the past, but none of the many routes has actually delivered more than just a few milligrams of product, where documented. The approach described herein is clearly more efficient; it hinges upon the first implementation of ruthenium-catalyzed trans-hydrogenation in natural products total synthesis....

Journal: :International Journal of Mass Spectrometry 2012

Journal: :Nature communications 2014
Aline Dantas de Araujo Mehdi Mobli Joel Castro Andrea M Harrington Irina Vetter Zoltan Dekan Markus Muttenthaler JingJing Wan Richard J Lewis Glenn F King Stuart M Brierley Paul F Alewood

Poor oral availability and susceptibility to reduction and protease degradation is a major hurdle in peptide drug development. However, drugable receptors in the gut present an attractive niche for peptide therapeutics. Here we demonstrate, in a mouse model of chronic abdominal pain, that oxytocin receptors are significantly upregulated in nociceptors innervating the colon. Correspondingly, we ...

Journal: :Molecules 2013
Xufen Yu Dianqing Sun

Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical molecules. So far, a large number of macrocyclic natural products have been isolated and synthesized. The construction of macrocycles is generally considered as a crucial and challenging step in the synthesis of macrocyclic natural products. Over the last several decades, numerous efforts have been underta...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید