The aim of this study was to design orally disintegrating tablets of Olanzapine and to complex Olanzapine with 2-hydroxypropyl-β- cyclodextrin with special emphasis on disintegration and dissolution studies. Phase solubility studies demonstrated the formation of 1:1 molar inclusion complex by kneading method. Tablets were prepared by using superdisintegrants namely, sodium starch glycolate, cro...

Photocatalytic processes are more and more widely used to remove different pollutants including microorganisms from liquid and gaseous media. However, methods for evaluating the efficiency of photocatalysts at inactivation/disintegration of microorganisms in the liquid film have limitations at predicting their efficiency for microorganism-containing aerosols. The comparison of two types of phot...

The Diversity and pluralism of the Indonesian nation are adhered to by motto Bhineka Tunggal Ika Pancasila as basis state nation's outlook on life. Globalization has resulted in a degradation character indicated increase intolerance radicalism well decline spirit nationalism patriotism which have created threats national disintegration. This study aims revitalize facing effects globalization or...

The objective of the present work was to optimize the formulation of fast disintegrating tablets (FDTs) of ondansetron HCl containing novel superdisintegrants, possessing sufficient mechanical strength and disintegration time comparable to those containing crospovidone or croscarmellose sodium. The FDTs were formulated using a novel superdisintegrant (chitosan-alginate (1:1) interpolymer comple...

OBJECTIVE To investigate the disintegration profile, acceptability, and tolerability of orally disintegrating risperidone tablets in patients with schizophrenia or schizoaffective disorder. METHOD Ten patients stable for at least 10 days on monotherapy with oral risperidone 2 mg to 4 mg taken once daily were switched for 7 days to an equivalent dosage of orally disintegrating risperidone. Vis...

The polyherbal decoction, Gulugulutitakam is known for the treatment of various inflammatory conditions. For the ease of administration, this dosage form has been converted into tablets containing high amount of dry extract but it has the disadvantage of longer disintegration and dissolution parameters. In our attempt to develop tablets with improved disintegration and dissolution time, we have...

Pramipexole is the mostly prescribed drug in patients with Parkinson disease. The incidence of Parkinson disease is related to aging and mostly developed in elderly people with difficulty in swallowing or dysphagia. In the current study we aimed to develop an orally fast disintegrating tablet (ODT) of pramipexole as a preferable alternative in geriatric patients. Hence, the fast disintegration ...

Nano-fibrillated cellulose was produced from flax and wheat straw cellulose pulps by high pressure disintegration. The reinforcing potential of both disintegrated nano-celluloses in a polyvinyl-alcohol matrix was evaluated. Disintegration of wheat straw was significantly more time and energy consuming. Disintegration did not lead to distinct changes in the degree of polymerization; however, the...

RZT is potent anti migraine drug having agonist activity at the 5-hydroxytryptamine (5-HT) 1B and 5-HT 1D receptor. It commonly used for relief of headaches in treatment of migraine. Conventional tablets of RZT are not capable of rapid action, which is required for immediate relief from migraine pain. Marketed freeze dried tablet of RZT is available. Freeze drying is cumbersome and it yields a ...

BACKGROUND AND PURPOSE Histotripsy is a nonthermal focused ultrasound technology that uses acoustic cavitation to homogenize tissue. Previous research has demonstrated that the prostatic urethra is more resistant to histotripsy effects than prostate parenchyma, a finding that may complicate the creation of transurethral resection of the prostate-like treatment cavities. The purpose of this stud...