Layered double hydroxide (LDH) nanoparticles were prepared and used as solid support for superoxide dismutase (SOD) enzymes. Structural features were studied by XRD, spectroscopic methods (IR, UV-Vis and fluorescence) and TEM, while colloidal stability of the obtained materials was investigated by electrophoresis and light scattering in aqueous dispersions. The SOD quantitatively adsorbed on th...

The present research work was focussed on the preparation as well as the evaluation of Aceclofenac solid dispersions for analgesic, anti-inflammatory and immunosuppressant activities. Solid dispersions were formulated using cros-carmellose sodium as polymer in different ratios. The solid dispersions were prepared using physical mixture, solvent evaporation and kneading techniques. The solid dis...

The main purpose of this research was to study the mechanism of drug release from solid dispersions of albendazole, giving special emphasis to particle size of the drug in solid dispersions. Solid dispersions were prepared using three different carriers, mixing ratios and methods in an attempt to improve the solubility and dissolution rate of albendazole. The mechanism of enhanced dissolution w...

Buckypaper are self-supporting films of carbon nanotubes (CNT), which can be used as electrodes, nano filter or for the reinforcement of polymers, for instance. Usually they are produced by filtration of CNT dispersions. The disadvantages of filtration process are discontinuous operation, long duration of filtration and limited size of the buckypaper. The aim of this project was to develop a sp...

Ibuprofen is one of the most important non-steroidal anti-inflammatory drugs used in the treatment of inflammatory diseases. In its pure state, ibuprofen presents poor physical and mechanical characteristics and its use in solid dosage forms needs the addition of excipients that improve these properties. The selection of the best excipients and the most suitable pharmaceutical dosage form to ca...

Rheology is demonstrated to be a sensitive and quantitative probe of weak attractive forces acting in concentrated stable colloidal dispersions through comparison of rheology and small-angle neutron scattering measurements on a model dispersion with added polyampholyte. Polyampholyte-stabilized dispersions are found to exhibit weak attractions in the form of depletion forces arising from free p...

In the present study, we prepared solid dispersions of water-insoluble and soluble drugs (ethenzamide (ETZ) and theophylline (THEO)) by the twin screw extruder method, which made it possible to control both kneading and heating at the same time under the fusion point of each drug, using three types of the controlled-release high-molecular-weight substance Carbopol (CAR) as the carrier. The soli...

This work explores the use of both spray drying and d-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging were also conducted. The resu...

Carbamazepine is a water-insoluble antiepileptic drug. Being a BCS class-II drug, its absorption is dissolution rate limited. Solid dispersions were prepared to enhance the dissolution rate of the drug. Crospovidone and croscarmellose sodium were used as the hydrophilic carriers. Solid dispersions showed a remarkable enhancement in the dissolution rate of the drug. In the present research work,...

The utilization of intravenously administered aqueous dispersions of carotene has been investigated by a number of workers (e.g. Church, MacVicar, Bieri, Baker & Pope, 1954; Bieri & Pollard, 1954; Bieri, 1955; Kon, McGillivray & Thompson, 1955; McGillivray, Thompson & Worker, 1956), and it is now clearly established that carotene so administered can be converted into vitamin A in rats, rabbits,...