Gemtuzumab ozogamicin (GO) is a recombinant humanized immunoglobulin G4 anti-cluster of differentiation (CD)33 monoclonal antibody conjugated to N-acetyl-γ calicheamicin dimethylhydrazide, a naturally potent antibiotic. It has been introduced for the treatment of acute promyelocytic leukemia (APL), since large quantities of CD33 are commonly expressed on the surface of APL cells. The present st...

To provide more information on the pathways of fibrinogen catabolism in generalized cancer. the effect of heparin on fibrinopeptide A (fpA) and on 1251-fibrinogen kinetics was studied in 1 5 patients with disseminated neoplasia. Three patients had evidence of venous thrombosis and in 2 additional patients a low fibrinogen level together with increased amounts of FDP/fdp and a positive ethanol t...

Disseminated intravascular coagulopathy (DIC) (see Figure 1) is a complex, life-threatening condition that causes a hypercoagulative state, resulting in inappropriate activation of the coagulation cascade (see Figure 2). Activation of the coagulation cascade is triggered by the release of tissue factor (TF), a transmembrane glycoprotein (McCance & Huether, 2006). On release of TF, the coagulati...

The etiology of decompression sickness is discussed from the point of view of its historical development from 1670 (Robert Boyle) to the present. A number of authors are cited who have called attention to circumstances unexplained by the bubble theory, and pointing to the existence of other mechanisms in the production of decompression sickness. The concept of disseminated intravascular coagula...

The severity of sepsis increases along with the degree of coagulation disorder, and a fulminant coagulation abnormality is recognized as disseminated intravascular coagulation (DIC). The mortality in sepsis‑associated DIC remains as high as 40%, which is comparable to that in septic shock. Even though intensive research is ongoing, there is currently no established therapy for this life‑threate...

Cardiac surgery and extracorporeal membrane oxygenation (ECMO) both are thrombogenic procedures, wherein coagulopathy ensues. However, patients who bleeding need not to be coagulopathic. Hemodilution, hypothermia, acidosis all worsen coagulopathy. If this process continues, without correction, a consumptive with dilution (disseminated intravascular coagulation [DIC]) is formed, immense morbidit...

To provide more information on the pathways of fibrinogen catabolism in generalized cancer. the effect of heparin on fibrinopeptide A (fpA) and on 1251-fibrinogen kinetics was studied in 1 5 patients with disseminated neoplasia. Three patients had evidence of venous thrombosis and in 2 additional patients a low fibrinogen level together with increased amounts of FDP/fdp and a positive ethanol t...

Introduction Overt disseminated intravascular coagulation (DIC) develops in half of the septic patients by the fifth day, leading to double mortality in sepsis. Hypercoagulability, inevitably present before depletion of clotting factors and platelets, is hardly detected by available screening tests [1,2]. This, in turn, prevents the development of targeted therapy at early stages of DIC. Global...

OBJECTIVES To measure the D-dimer concentrations in both healthy dogs and dogs with and without evidence of thromboembolic disease/disseminated intravascular coagulation using a "Point-of-Care" test. METHODS Sixty-seven clinical cases and 26 healthy dogs were included in this retrospective study. D-dimer was measured using the NycoCard D-dimer test. Clinical conditions were categorised based ...

Knowing the pathophysiology of trauma-induced coagulopathy is important for the management of severely injured trauma patients. The aims of this review are to provide a summary of the recent advances in our understanding of thrombosis and hemostasis following trauma and to discuss the pathogenesis of disseminated intravascular coagulation (DIC) at an early stage of trauma. Local hemostasis and ...