The transmembrane topology of acetylcholine receptor (AChR) delta subunit, synthesized in vitro and co-translationally integrated into dog pancreas rough microsomal membranes, was studied using limited proteolysis and domain-specific immunoprecipitation. Forty-four kilodaltons (kd) of the 65-kd delta subunit comprise a single fragment that is inaccessible to exhaustive proteolytic digestion fro...

Pollen tube growth depends on the differential distribution of organelles and vesicles along the tube. The role of microtubules in organelle movement is uncertain, mainly because information at the molecular level is limited. In an effort to understand the molecular basis of microtubule-based movement, we isolated from tobacco pollen tubes polypeptides that cosediment with microtubules in an AT...

Results 197 new cases of PSV were diagnosed during these years – HSP in 154, KD in 35, Churg-Staruss syndrome in 2, and polyarteritis nodosa in 3 cases, respectively. Wegener granulomatosis, microscopic polyangiitis and hypocomplementaemic urticarial vasculitis were all diagnosed in one patient. The age distribution ranged from 3 months to 16 years, in cases of KD – from 2 months to 13 years. 3...

An antibody was detected in the sera from patients with systemic lupus erythematosus (SLE) and central nervous system (CNS) involvement that reacted with a 50-kD antigen in the plasma membrane of brain synaptic terminals. The 50-kD antigen was solubilized with Triton X-100 from preparations enriched with synaptic plasma membranes, and was partially purified by molecular sieve filtration column ...

A new protein found at sites of cell-substrate adhesion has been identified by analysis of a nonimmune rabbit serum. By indirect immunofluorescence this serum stains focal contacts (adhesion plaques) and the associated termini of actin filament bundles in cultured chicken cells. Western immunoblot analysis of total chick embryo fibroblast protein demonstrated an 82-kD polypeptide to be the majo...

A new parallel programming approach based on the structured co-ordination of parallel behaviour is applied to programming the Fujitsu AP1000 for mixed parallel vector and scalar computation. With such a structured parallel programming model resource organisation as well as data and computation distribution can be programmed at a high level. The performance of a program can also be systematicall...

A cake is a metaphor for a heterogeneous, divisible good, such as land. A perfect division of cake is efficient (also called Pareto-optimal), envyfree, and equitable. We give an example of a cake in which it is impossible to divide it among three players such that these three properties are satisfied, however many cuts are made. It turns out that two of the three properties can be satisfied by ...

Fair Division, unlike most research on fairness in the social sciences and mathematics, is devoted solely to the analysis of constructive procedures for actually dividing things up and resolving disputes, including...