CD47 is a ligand of the inhibitory receptor, signal regulatory protein (SIRP)alpha, and its interaction with SIRPalpha on macrophages prevents phagocytosis of autologous hematopoietic cells. CD47-SIRPalpha signaling also regulates dendritic cell (DC) endocytosis, activation, and maturation. In this study, we show that CD47 expression on donor cells plays an important role in suppression of allo...

It has been shown that peripheral-blood mononuclear leukocytes (MNL) are responsible for transfusion-induced alloimmunization to donor major histocompatability complex (MHC) antigens. However, it is not known which subset of MNL is responsible for this immune response. Because elimination of class-II MHC antigen-positive passenger leukocytes effectively prolongs the survival of allografts, it h...

The glucohexaose, beta-D-Glcp-(1-->3)-[beta-D-Glcp-(1-->3)-beta-D-Glcp-(1-->3)-beta-D-Glcp-(1-->6)]-beta-D-Glcp-(1-->3)-D-Glcp, was synthesized as its allyl glycoside via 3+3 strategy. The trisaccharide donor, 2,3,4,6-tetra-O-benzoyl-beta-D-glucopyranosyl-(1-->3)-2,4,6-tri-O-acetyl-beta-D-glucopyranosyl-(1-->3)-2,4,6-tri-O-acetyl-alpha-D-glucopyranosyl trichloroacetimidate (11), was obtained by...

a. Prophylactic treatment for Cytomegalovirus (CMV) is recommended in solid organ transplantation as it is associated with a significant decrease in CMV disease and infection compared with placebo or no treatment (approximately a 50% and 40% decrease in relative risk, respectively) (Level I evidence). b. The use of the antiviral agents oral valganciclovir, oral valaciclovir, and intravenous gan...

BACKGROUND & AIMS The lectin pathway of complement activation is a crucial effector cascade of the innate immune response to pathogens. Cytomegalovirus (CMV) infection occurs frequently in immunocompromised patients after orthotopic liver transplantation (OLT). Single-nucleotide polymorphisms (SNPs) in the lectin pathway genes determine their liver-derived protein level and functional activity....

Donor safety and preservation of donor health after living liver donation are of paramount importance. In addition, the preoperative mental state of a donor is an important factor in determining the psychological impact of donor hepatectomy. Thus, we aimed to explore the mental health status of living liver donors after hepatectomy. We enrolled 60 donors who were scheduled to undergo living don...

A common strategy used to dismiss arguments against donor conception is that there is no proof donor-conceived persons are harmed in any important way. Their claims of harm are dismissed as anecdotal and "not scientific," and studies carried out on young donor-conceived children, who declare themselves perfectly happy with their parents and families are tendered as evidence that no harm is caus...

dear editor:   sir, rabies is an important neurological infection. it is deadly and it is not possible to treat it. despite the attempt for rabies control via animal control and rabies vaccination, there are many reported cases of rabies in each year. basically, the transmission of rabies is due to animal bite. recently, the new mode of rabies transmission, human to human, via transplantation i...