A double blind trial of a single 40 mg dose of the beta adrenergic blocking agent propranolol in the treatment of essential tremor produced significant reduction of tremor in four of five patients, but this effect was transient and had considerably diminished within four hours. A month's double blind clinical trial of propranolol, in a dose of 30 mg three times a day, showed that the active dru...

Contagious yawning is thought to represent a basic form of empathy involved in state matching. Despite recent evidence in support of this connection, the neurochemical basis of contagious yawning remains largely unknown. Here, we investigate whether intranasal oxytocin, a hormone and neuropeptide involved in empathic processing, bonding and social affiliation, influences contagious yawning amon...

Despite a multitude of ingenious ideas, a review of the literature has revealed no consistently acceptable results concerning adhesion prophylaxis. While pharmacologic avenues are far from exhausted, presently, there is no acceptable regimen. A double blind experimental study was performed with 130 Sprague-Dawley rats to determine the effect of high intensity low frequency sound on postoperativ...

This corrects the article DOI: 10.1038/srep38795.

OBJECTIVE The aim of this study was to evaluate the effect of combined hearing and tinnitus masking devices that are appropriately programmed for acoustic stimulations using wide-band noise over the specific frequency range of tinnitus. MATERIAL AND METHODS A total of 21 patients were randomly divided into 2 groups. Group I (12 patients) was managed with betahistine dihydrochloride (2HCl) and...

BACKGROUND This study is an extension of a 28-week, randomized, double-blind, placebo-controlled study of memantine in 252 patients with moderate to severe Alzheimer disease. OBJECTIVE To evaluate long-term memantine treatment in moderate to severe Alzheimer disease. DESIGN, SETTING, AND PATIENTS Open-label, 24-week extension trial. Raters remained blind to the patients' initial study treat...

The current approach to assessing the quality of evidence obtained from clinical trials focuses on three dimensions: the quality of the design (with double-blinded randomised controlled trials representing the highest level of such design); the statistical power (beta) and the level of significance (alpha). While these aspects are important, we argue that other significant aspects of trial qual...

BACKGROUND A sedentary life without sufficient physical activity is recognized as a risk factor for various diseases, and a major modifiable risk factor for noncommunicable diseases. This study was conducted to investigate the effect of intervention using socioecological model in promoting women's physical activity in the city of Kerman, Iran. MATERIALS AND METHODS In this randomized, double-...

Recent bargaining experiments demonstrated an impact of anonymity and incomplete information on subjects’ behavior. This has rekindled the question whether “fair” behavior is inspired by regard for others or is explained by external forces. To test for the importance of external pressure we compare a standard double blind dictator game to a treatment which provides no information about the sour...

This study was to investigate whether a single dose of methylphenidate (MPH), a dopamine and noradrenaline enhancing drug for the treatment of attentional deficits, influences mismatch visual information processing in young healthy volunteers determined with N270. A randomized double-blinded placebo-controlled study was conducted, and each participant was tested on two sessions separated by two...