The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRLlpr mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRLlpr mice show reduced signs of renal pathogenesis, while other parameters such as mean survival time...

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W. B. Downs (Amer J Orthodont 34:812, 1948) presented findings from a study to determine the "normal range of variation" for certain variables that represented components of the dentofacial complex. He studied the distribution of these variables in 20 individuals with "clinically excellent occlusions," who ranged in age from 12 to 17 years and who were about equally divided with respect to sex....