Cyclin-dependent kinase 6 (Cdk6) is a D-Cyclin-activated kinase that is directly involved in driving the cell cycle through inactivation of pRB in G₁ phase. Increasingly, evidence suggests that CDK6, while directly driving the cell cycle, may only be essential for proliferation of specialized cell types, agreeing with the notion that CDK6 also plays an important role in differentiation. Here, e...

Aiming at the features of Plug-in Hybrid Electric Vehicles (PHEV) which can be charged through the network, the moving process of starting the engine was analyzed; the vehicle energy management strategy was formulated by combing of pure electric control strategy and economic model control strategy. Using genetic algorithm to optimize the upper and lower fluctuation limit values of state of char...

INTRODUCTION Drink driving incidents in the Australian community continue to be a major road safety problem resulting in a third of all fatalities. Drink driving prevalence remains high; with the rate of Australians who self report drink driving remaining at 11%-12.1% [1,2]. The focus of research in the area to date has been with recidivist offenders who have a higher probability of reoffending...

Driving while impaired (DWI) is a grave and persistent high-risk behavior. Previous work demonstrated that DWI recidivists had attenuated cortisol reactivity compared to non-DWI drivers. This suggests that cortisol is a neurobiological marker of high-risk driving. The present study tested the hypothesis that this initial finding would extend to first-time DWI (fDWI) offenders compared to non-DW...

Context Regulation of the availability of alcohol has been found to be a very important factor in alcohol impaired driving, as well as other alcohol related problems. Such factors as minimum purchase age for alcohol, the density and location of alcohol outlets, and alcohol service and sales practices have all been found to be related to impaired driving. Recent research has added to knowledge a...

The study proposed to analyze the combined driving cycles and their effect on fuel consumption within Distrito Metropolitano de Quito. For this, a test protocol was established where orography of land, traffic density road infrastructure District were studied. These factors allowed evaluation through global positioning system canister in order systematically travel set roads distance, time, ave...

methamphetamine hydrochloride is a white to light brown crystalline powder, or clear chunky crystals resembling ice. the majority of street methamphetamine is produced in clandestine laboratories. the drug manufacturer states that patients should be informed that methamphetamine and amphetamine may impair the ability to engage in potentially hazardous activities such as driving a motor vehicle....

The present study examined the associations driving under the influence of (a) cannabis and (b) alcohol, and motor vehicle collisions during, in a longitudinal study of a New Zealand birth cohort (n=936). Participants reported significantly (p<.0001) greater rates of driving under the influence of cannabis than driving under the influence of alcohol during ages 21-25. Also, there were statistic...

Ignition interlocks are effective in reducing recidivism among driving while intoxicated (DWI) offenders while installed on their vehicles. However, the devices are not widely used in the USA. This survey gauged public support for requiring ignition interlocks for all convicted DWI offenders including first-time offenders. 69% of respondents supported such a policy. Support was lowest (38%) amo...