Nanotechnology is providing a new therapeutic paradigm by enhancing drug efficacy and preventing side-effects. Edelfosine is a synthetic ether lipid analogue of platelet activating factor with high antitumor activity. The encapsulation of this potent antitumor drug in lipid nanoparticles increases its oral bioavailability; moreover, it prevents the hemolytic and gastrointestinal side-effects of...

Solid lipid nanoparticles have been increasingly utilised for improving oral bioavailability of drugs. Simvastatin is biopharmaceutical class 2 drug with poor oral bioavailability of 5%. In the present study, simvastatin solid lipid nanoparticles were successfully prepared by hot melt emulsification process and optimised with respect to surfactant and lipid concentration, and drug loading. The ...

Lipid formulations can improve the bioavailability of drugs that have low aqueous solubility. A variety of chemical compounds, including triglyceride oils (lipids), fatty acid esters and surfactants, can be included in lipid formulations. This heterogeneity makes spectroscopic study of the in ternal structure of formulation difficult. Understanding of lipid formulations at a molecular level wil...

Abbreviations: CARE, Cholesterol and Recurrent Events; LIPID, Long-term Intervention with Pravastatin in Ischaemic Disease. Corresponding author: Professor Chris Packard, fax +44 (0)141 211 4322, email [email protected] CAB InternationalPNSProceedings of the Nutrition Society (2000)0029-6651© Nutrition Society 2000 593 59423Cardiovascular disease risk: lifestyle v. drugsC. Packard423 ...

With an increasing number of lipophilic drugs under development, homolipids and heterolipids have gained renewed interests as excipients for oral drug delivery systems. Oral administration has many advantages for chronic drug therapy. It is relatively safe, convenient for the patient and allows self administration. This article is not intended to review the broad area of lipid-based vehicle for...

Lipid based drug delivery systems have been widely studied and reported over the past decade and offer a useful alternative to other colloidal drug delivery systems. Skin is a popular route of drug delivery for locally and systemically acting drugs and nanoparticles are reported as a potential formulation strategy for dermal delivery. Although the skin acts as a natural physical barrier against...

To the Editor: We appreciate the editorial comments provided by Drs Gotto and Kuller1 on our article published in the January 15, 2002, issue of Circulation,2 but we wish to respond to several issues raised. The methodology used to project population size is standard for the Third National Health and Nutrition Examination Survey (NHANES III) and is described thoroughly in the publication by the...

Some fifty years ago the Canadian pathologist Rudolf Altschul discovered that nicotinic acid in gram doses lowered plasma cholesterol in man, an effect surprisingly not shared by nicotinamide [1]. Altschul had also shown that nicotinic acid lowered plasma cholesterol and reduced aortic atherosclerosis in the cholesterol-fed rabbit. At that time, 5 years before bile acid sequestrants and 6-8 yea...

Abstract Pyrazinamide (PZA), a medication for tuberculosis, has high aqueous solubility and low permeability, undergoes extensive liver metabolism, exhibits toxicity through its metabolites. To avoid this, PZA in lipid core-shell nanoarchitectonics been formulated to target lymphatic uptake provide metabolic stability the incorporated drug. The UPLC-MS/MS method reliable vitro quantitative anal...

Proton nuclear magnetic resonance (NMR) spectroscopy, histological lipid staining, and electron microscopy were used to assess the biochemical and structural changes induced by treating the cultured human breast cell line HBL-100 with the cationic lipophilic phosphonium salts p-(triphenylphosphoniummethyl) benzaldehyde chloride (drug A) and [4-(hydrazinocarboxy)-1-butyl] tris-(4-dimethylaminoph...