b a ckground: cockroaches are among the medically important pests found within the human habitations that cause serious public health problems. they may harbor a number of pathogenic bacteria on the external surface with anti- biotic resistance. hence, they are regarded as major microbial vectors. this study investigates the prevalence and antibiotic resistance of gram-negative pathogenic bacte...

The resistance of pathogenic bacteria to antibiotics is increasing due with incorrect doses, wrong diagnostics, and the target. Bacteria that have been resistant several are called multi-drug organisms (MDRO) bacteria. Bacterial some requires alternative herbal treatments, one which Chromolaena odorata L. Research must therefore be conducted on antibacterial activity ethanol extract fraction C....

Gram-negative bacteria cause the majority of highly drug-resistant bacterial infections. To cross outer membrane complex cell envelope, antibiotics permeate through porins, trimeric channel proteins that enable exchange small polar molecules. Mutations in porins contribute to development phenotypes. In this work, we show a single point mutation porin PorB from Neisseria meningitidis, causative ...

Background and Objective: Diabetes mellitus is one of the main problems in health systems in the world. Diabetic Foot infections (DFI) is one of the main complications and the most cause  of non-traumatic lower limb amputation .This study aimed to determine the prevalence of bacteria involved in DFI and their antibiotic resistance in patients with DFI diagnosis. Patients and Metho...

conclusions induction of coccoid form of p. aeruginosa may be one of the important reasons for antibiotic treatment failure; therefore, prescribed dose of antibiotics should be carefully managed to prevent increasing antibiotic resistance and coccoid bacteria induction. results all used antibiotics at sub mic concentration had capability to induce coccoid bacteria. the highest rate of induced c...

Despite the fact that selective pressure of antibiotics on wild birds is supposed to be very weak, they are considered potential vectors antimicrobial resistance (AMR). Obligate scavengers such as vultures can present high proportions extended-spectrum cephalosporins (ESC) and multi-drug-resistant (MDR) bacteria, partially due feeding stations provisioned with livestock carcasses from intensive...

Eravacycline is a novel antibiotic of the tetracycline class with activity against broad spectrum clinically significant bacteria, including multi-drug-resistant organisms. For this reason, it may be an alternative to treating critical infections etiology. We aimed assess in vitro effectiveness eravacycline carbapenemase-producing Gram-negative bacilli clinical isolates identified hospitals Łód...

Antimicrobial resistance is a major world health concern and drug-resistant Staphylococcus aureus serious threat. Due to the emergence of multidrug-resistant bacterial strains, there an urgent need develop novel drug targets meet challenge organisms. The main objective current study was determine molecular against S. using by computational approach. cultured in brain heart infusion broth medium...

OBJECTIVE The rising occurrence of drug-resistant pathogens accentuates the need to identify novel antibiotics. We wanted to identify new scaffolds for drug discovery by repurposing FDA-approved drugs against Acinetobacter baumannii, an emerging Gram-negative nosocomial drug-resistant pathogen. MATERIALS AND METHODS In this study, we screened 1040 FDA-approved drugs against drug-susceptible A...